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Investigation of Anti-Toxocara and Anti-Toxoplasma Antibodies in Patients with Schizophrenia Disrder

机译：精神分裂症患者抗弓形虫和弓形虫抗体的研究

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Objective. The aim of the present study was to examine the relationship between Toxoplasma gondii and Toxocara spp. infections in patients with schizophrenia disorder. Method. A total of 100 patients with schizophrenia disorder and 95 healthy individuals participated in the study. Participants were tested for the presence of anti-T. gondii and znti-Toxocara spp. antibodies by ELISA and Western blotting. Data were analyzed using Chi-square test and Fisher9s exact test. Results. There were no differences in T. gondii IgG seroprevalence between patients with schizophrenia and healthy individuals (P = 0.1), but there were differences in seroprevalence between males and females with schizophrenia (P = 0.009). In contrast, Toxocara spp. IgG seroprevalence was greater in patients with schizophrenia disorder than in healthy individuals (P = 0.02), but there were no differences in seroprevalence between men and women with schizophrenia (P = 0.5). Finally, there were no differences in seroprevalence of T. gondii or Toxocara spp. IgG among different subtypes of schizophrenia, various age groups, residential area, or clinical course of treatment (P > 0.05). Conclusion. The present study suggests that patients with schizophrenia disorder are at elevated risk of Toxocara spp. infection. Moreover, contamination with T. gondii is a risk factor for schizophrenia in women.
机译：目的。本研究的目的是研究弓形虫与弓形虫之间的关系。精神分裂症患者的感染。方法。共有100位精神分裂症患者和95位健康个体参加了研究。测试参与者的抗-T的存在。贡迪和znti-Toxocara spp。 ELISA和Western印迹检测抗体。使用卡方检验和Fisher9s精确检验对数据进行分析。结果。精神分裂症患者和健康个体之间的弓形虫IgG血清阳性率没有差异（P = 0.1），但男性和女性精神分裂症患者的血清阳性率也存在差异（P = 0.009）。相反，Toxocara spp。精神分裂症患者的IgG血清阳性率高于健康个体（P = 0.02），但精神分裂症的男性和女性之间的血清阳性率无差异（P = 0.5）。最后，弓形虫或Toxocara spp的血清阳性率没有差异。不同精神分裂症亚型，不同年龄段，居住地区或临床治疗过程中的IgG（P> 0.05）。结论。本研究表明精神分裂症患者的弓形虫风险较高。感染。此外，弓形虫的污染是女性精神分裂症的危险因素。

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