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首页> 外文期刊>Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG >Clinical characteristics of 195 Japanese sarcoidosis patients treated with oral corticosteroids.
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Clinical characteristics of 195 Japanese sarcoidosis patients treated with oral corticosteroids.

机译：口服皮质类固醇激素治疗的195例日本结节病患者的临床特征。

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摘要

Questionnaires were sent to 46 hospitals of all over Japan in order to obtain the clinical data on sarcoidosis patients who were treated with oral corticosteroids. The number of female patients was greater than that of male patients (1.5:1), and the average age was 44.9 +/- 16.5 with peaks at 20 and at 50 to 60. The markers of disease activity were high in serum or bronchoalveolar lavage fluids (BALF): specifically, the serum angiotensin-converting enzyme (sACE) was 27.9 +/- 31.9 IU/ml (n.v. < 21.4), and the CD4/CD8 lymphocyte ratio was 6.5 +/- 5.7. Eye involvement was the most common reason for systemic steroid therapy, followed in order by lung and heart involvement. The main reasons for steroid therapy were the exacerbation of ocular symptoms, visual disturbance, respiratory symptoms, such as cough or exertional dyspnea, progression of chest radiographic findings, heart failure and severe arrhythmia, such as AV block. The initial corticosteroid dose was usually 30 mg of predinisolone per day, but for some refractory cases, a 40-60 mg per day was used. Immunosuppressive drugs, such as methotrexate, were also used in the small number of patients who responded poorly to the steroid. Overall, a good clinical response to the drug was found in 70-80% of the steroid treated patients, but in those with cardiac disease, the response rate was only 48%.
机译：为了向结节病患者口服皮质类固醇激素治疗的临床数据，问卷被发送到日本全国46家医院。女性患者数量多于男性患者（1.5：1），平均年龄为44.9 +/- 16.5，在20岁时和50至60岁时达到峰值。在血清或支气管肺泡灌洗液中疾病活动的标志物很高体液（BALF）：具体而言，血清血管紧张素转化酶（sACE）为27.9 +/- 31.9 IU / ml（nv <21.4），CD4 / CD8淋巴细胞比率为6.5 +/- 5.7。眼睛受累是全身类固醇治疗的最常见原因，其次是肺和心脏受累。类固醇治疗的主要原因是眼部症状，视觉障碍，呼吸道症状（如咳嗽或劳累性呼吸困难）加重，胸部影像学检查进展，心力衰竭和严重心律不齐（如房室传导阻滞）。皮质类固醇的初始剂量通常为每天泼尼松龙30 mg，但对于某些难治性病例，每天使用40-60 mg。免疫抑制药物，例如甲氨蝶呤，也用于少数对类固醇反应不良的患者。总体而言，在接受类固醇治疗的患者中，有70-80％的人对该药有良好的临床反应，但在心脏病患者中，其反应率仅为48％。

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