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首页> 外文期刊>Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG >Sarcoidosis: genes and microbes--soil or seed?
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Sarcoidosis: genes and microbes--soil or seed?

机译：结节病：基因和微生物-土壤还是种子？

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摘要

Sarcoidosis is a multi-organ granulomatous disorder that is characterised by the accumulation of CD4+ T-lymphocytes resulting in a Th-1 type immune response. Although our understanding of the immune response in sarcoidosis has improved in recent years through studies of bronchoalveolar lavage cells and fluid, the genetic predisposition and trigger factors (and their interrelationship) remain unclear. Previous reports of familial clustering and varying prevalence of sarcoidosis in different populations suggested molecular epidemiological heterogeneity. This review focuses specifically on two pivotal areas that have been the subjects of intensive investigation recently: a) triggering by infective agents and b) host genetic susceptibility and relates these to broader issues of pathogenesis. It is concluded that one or more microbes behaving in a non-infectious fashion in a genetically predisposed individual trigger the sarcoidosis granulomatous response.
机译：结节病是一种多器官肉芽肿性疾病，其特征在于CD4 + T淋巴细胞的积累导致Th-1型免疫反应。尽管通过研究支气管肺泡灌洗细胞和体液，近年来我们对结节病免疫反应的认识有所提高，但遗传易感性和触发因素（及其相互关系）仍不清楚。以前有关不同人群中的族群聚集和结节病患病率的报道表明分子流行病学具有异质性。这篇综述特别关注了两个关键领域，这些领域最近已成为深入研究的主题：a）由感染因子触发和b）宿主遗传易感性，并将其与更广泛的发病机理相关联。结论是，在遗传易感个体中以非感染方式表现的一种或多种微生物触发结节病肉芽肿反应。

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