Microsatellite instability analysis of sinonasal carcinomas.

Martinez JG; Perez-Escuredo J; Lopez F; Suarez C; Alvarez-Marcos C; Llorente JL; Hermsen MA

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Microsatellite instability analysis of sinonasal carcinomas.

机译：鼻窦癌的微卫星不稳定性分析。

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OBJECTIVES: Intestinal-type sinonasal adenocarcinoma (ITAC) and squamous cell carcinoma of the nasal cavity (SCCNC) are histopathologically but not etiologically similar to colorectal adenocarcinoma or to laryngeal squamous cell carcinoma, respectively. Microsatellite instability (MSI) is involved in both tumors. The aim of this study was to investigate a possible role for MSI in the pathogenesis of two types of nasal carcinoma. MATERIAL AND METHODS: DNA obtained from frozen tumor samples of 41 ITACs and 24 SCCNCs was analyzed for shifts in five mononucleotide microsatellite loci by multiplex PCR. RESULTS: The allelic patterns of one ITAC (2%) and five SCCNCs (21%) revealed an allelic shift for at least one of the five loci, indicating microsatellite instability. CONCLUSION: MSI may be involved in squamous cell carcinoma, but not in adenocarcinoma of the nasal cavities.

机译：目的：肠型鼻窦腺癌（ITAC）和鼻腔鳞状细胞癌（SCCNC）在病理学上与结直肠腺癌或喉鳞状细胞癌分别不同。两种肿瘤均涉及微卫星不稳定性（MSI）。这项研究的目的是调查MSI在两种类型的鼻癌发病机理中的可能作用。材料与方法：通过多重PCR分析了从41个ITAC和24个SCCNC的冷冻肿瘤样品中获得的DNA的5个单核苷酸微卫星基因座的变化。结果：一个ITAC（2％）和五个SCCNCs（21％）的等位基因模式显示了五个位点中至少一个的等位基因转移，表明微卫星不稳定。结论：MSI可能参与鳞状细胞癌，但不涉及鼻腔腺癌。

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《Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery》 |2009年第1期|共6页
作者
Martinez JG; Perez-Escuredo J; Lopez F; Suarez C; Alvarez-Marcos C; Llorente JL; Hermsen MA;
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正文语种 eng
中图分类耳鼻咽喉科学;外科学各论;
关键词
N-methylsuccinimide; Microsatellite Repeats; Nasal; Adenocarcinoma; Carcinoma; Squamous Cell; 微随体重复; 腺癌; 癌; 鳞状细胞;

机译：N-methylsuccinimide;Microsatellite Repeats;Nasal;Adenocarcinoma;Carcinoma;Squamous Cell;微随体重复;腺癌;癌;鳞状细胞;

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1. Microsatellite instability analysis of sinonasal carcinomas. [J] . Martinez JG, Perez-Escuredo J, Lopez F, Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery . 2009,第1期

机译：鼻窦癌的微卫星不稳定性分析。
2. B-Raf mutations, microsatellite instability and p53 protein expression in sporadic basal cell carcinomas. [J] . Stamatelli A, Saetta AA, Bei T, Pathology oncology research: POR . 2011,第3期

机译：散发性基底细胞癌中的B-Raf突变，微卫星不稳定性和p53蛋白表达。
3. Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas. [J] . Huang YW, Luo J, Weng YI, Gynecologic Oncology: An International Journal . 2010,第2期

机译：CIDEA，HAAO和RXFP3的启动子高甲基化与子宫内膜癌中的微卫星不稳定性有关。
4. Analysis of LOH, Microsatellite Instability and Gene Studies with DNA-Microarray Technology, in High Risk Population for Gastric Cancer [C] . A. Rinnovati, G. Marseglia, A. Magi, International Gastric Cancer Congress . 2005

机译：LOH，微卫星不稳定性和基因研究与DNA微阵列技术，胃癌高风险群体
5. Mutation profiling in colorectal cancer patients with microsatellite instability; High frequency of BRCA2 and EGFR somatic mutations [D] . Deihimi, Safoora. 2016

机译：具有微卫星不稳定性的大肠癌患者的突变谱； BRCA2和EGFR体细胞突变的频率高
6. Transforming growth factor-beta receptor type 2 mutations and microsatellite instability in sporadic colorectal adenomas and carcinomas. [O] . W. S. Samowitz, M. L. Slattery 1997

机译：散发性结直肠腺瘤和癌中的转化生长因子-β2型受体突变和微卫星不稳定性。
7. Comparison of the Microsatellite Instability Analysis System and the Bethesda Panel for the Determination of Microsatellite Instability in Colorectal Cancers [O] . Murphy, Kathleen M., Zhang, Shengle, Geiger, Tanya, 2006

机译：微卫星不稳定性分析系统与Bethesda面板用于确定结直肠癌微卫星不稳定性的比较

Microsatellite instability analysis of sinonasal carcinomas.

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