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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Molecular markers of micrometastasis in oral cavity carcinomas.
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Molecular markers of micrometastasis in oral cavity carcinomas.

机译：口腔癌微转移的分子标志物。

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OBJECTIVE: To examine the expression of candidate markers for micrometastasis. STUDY DESIGN: Cross-sectional analysis of subjects with oral cavity carcinomas who underwent sentinel lymph node biopsy (SLNB) and subsequent immunohistochemical (IHC) analysis. SUBJECTS AND METHODS: Two groups were identified based on SLNB status: negative SLNB (19/30) and positive SLNB (11/30). Specimens underwent IHC using conjugated monoclonal antibodies for membrane type-1 matrix metalloproteinase (MT1-MMP), CD44, focal adhesion kinase-1, and E-cadherin. Staining results were evaluated to determine if a particular marker was associated with SLNB status or other histopathologic prognosticators. RESULTS: For MT1-MMP, 21 percent (3/14) of evaluable specimens stained positively in the SLNB(-) group and 67 percent (4/6) stained positively in the SLNB(+) group (P=0.12). No statistically significant association was seen between any marker's staining pattern and SLNB status alone. When MT1-MMP staining was evaluated in tumors with SLNB(+) or perineural invasion (PNI) present on histopathology, six of nine specimens (67%) stained positively for MT1-MMP, vs one of 11 (9%) in specimens lacking either negative prognosticator (P=0.016, RR=7.33). CONCLUSION: Preliminary results suggest that MT1-MMP positivity in primary tumor specimens may identify aggressive tumor types, evidenced by the presence of micrometastasis or PNI.
机译：目的：探讨微转移候选标志物的表达。研究设计：对接受了前哨淋巴结活检（SLNB）和随后的免疫组化（IHC）分析的口腔癌患者进行横断面分析。研究对象和方法：根据SLNB状态分为两组：阴性SLNB（19/30）和阳性SLNB（11/30）。使用结合的单克隆抗体针对膜类型1基质金属蛋白酶（MT1-MMP），CD44，粘着斑激酶1和E-钙黏着蛋白对标本进行IHC。评估染色结果以确定特定标志物是否与SLNB状态或其他组织病理学预后相关。结果：对于MT1-MMP，SLNB（-）组中可评估的标本中有21％（3/14）呈阳性，而SLNB（+）组中67％（4/6）呈阳性（P = 0.12）。在任何标记的染色模式与单独的SLNB状态之间均未发现统计学上的显着关联。当在组织病理学上存在SLNB（+）或神经周围浸润（PNI）的肿瘤中评估MT1-MMP染色时，MT1-MMP阳性的9个标本中有6个（67％）呈阳性，而缺乏标本的11个标本（9％）中有1个任一个阴性预后因素（P = 0.016，RR = 7.33）。结论：初步结果表明，原发性肿瘤标本中MT1-MMP阳性可鉴定为侵袭性肿瘤类型，其表现为微转移或PNI。

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