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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma.
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Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma.

机译：鳞状细胞癌的肿瘤等级，微血管密度以及苹果酸脱氢酶，乳酸脱氢酶和己糖激酶的活性。

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摘要

Squamous cell carcinomas were evaluated with respect to tumor differentiation (through use of hematoxylin and eosin stain), microvessel density (through use of CD-34 immunocytochemical stain), and magnitudes of malate dehydrogenase (MDH), hexokinase, and lactate dehydrogenase (LDH) enzyme activities. Direct correlations were found between tumor grade, MDH activity, and microvessel density. Direct correlations were also found between hexokinase activity and MDH activity and microvessel density. Inverse correlations were found between LDH activity and both tumor grade and MDH activity. These results suggest that the high rate of glucose utilization (indicated by hexokinase activity) found in more poorly differentiated tumors has a higher component of aerobic oxidative metabolism (indicated by MDH activity) and a relatively lower contribution from anaerobic metabolism (indicated by LDH activity) than do the rates found in more differentiated tumors. It is also suggested that as the glycolytic rate increases, more pyruvate goes into the Krebs cycle than into lactate. The availability of glucose-derived pyruvate for oxidative metabolism would mean less of a dependency on glutamine as a carbon source in squamous cell carcinoma.
机译：评估鳞状细胞癌的肿瘤分化（通过使用苏木精和曙红染色），微血管密度（通过使用CD-34免疫细胞化学染色）以及苹果酸脱氢酶（MDH），己糖激酶和乳酸脱氢酶（LDH）的大小酶活性。在肿瘤等级，MDH活性和微血管密度之间发现直接相关性。还发现己糖激酶活性与MDH活性和微血管密度之间存在直接相关性。发现LDH活性与肿瘤等级和MDH活性之间呈负相关。这些结果表明，在分化较差的肿瘤中发现较高的葡萄糖利用率（以己糖激酶活性表示）具有较高的需氧氧化代谢成分（以MDH活性表示），而无氧代谢的贡献相对较低（以LDH活性表示）。比在更分化的肿瘤中发现的比率要高。还建议随着糖酵解速率的增加，进入克雷布斯循环的丙酮酸比进入乳酸的丙酮酸更多。葡萄糖衍生的丙酮酸可用于氧化代谢意味着在鳞状细胞癌中较少依赖谷氨酰胺作为碳源。

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