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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Loss of heterozygosity of tumor suppressor genes (p16, Rb, E-cadherin, p53) in hypopharynx squamous cell carcinoma.
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Loss of heterozygosity of tumor suppressor genes (p16, Rb, E-cadherin, p53) in hypopharynx squamous cell carcinoma.

机译：下咽鳞状细胞癌中肿瘤抑制基因（p16，Rb，E-cadherin，p53）的杂合性丧失。

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OBJECTIVE: Microsatellite alterations, especially those that cause loss of heterozygosity (LOH), have recently been postulated as a novel mechanism of carcinogenesis and a useful prognostic factor in many kinds of malignant tumors. However, few studies have focused on a specific site, hypopharynx. The aim of this study was to evaluate the relationship between LOH and hypopharyngeal squamous cell carcinoma (HPSCC). STUDY DESIGN: Laboratory-based study. SETTING: Integrated health care system. SUBJECTS AND METHODS: Matched normal and cancerous tissues from 30 patients with HPSCC were examined for LOH in 4 tumor suppressor genes (TSGs) (p16, Rb, E-cadherin, and p53) at loci 9p21, 13q21, 6q22, and 17p13, respectively, using microsatellite markers amplified by polymerase chain reaction. The results for each loci were compared with clinicopathological features. RESULTS: Among the 30 cases, 26 (86.7%) exhibited LOH, with the most common alteration being LOH at p53 (52.6%). Significantly higher rates of LOH detection were seen in Rb, p53, and the LOH-high group (cases where 2 or more loci with LOH were found) in cases of lymph node metastasis. Compared with stage I and II carcinoma, tumors of stages III and IV had significantly higher frequencies of LOH in Rb, p53, and the LOH-high group. However, the presence of LOH was not significantly correlated with survival. CONCLUSION: These results suggest that LOH in TSGs such as Rb and p53 may contribute to the development and progression of HPSCC. The presence of LOH in the primary tumor may also be predictive of lymph node metastasis.
机译：目的：微卫星改变，特别是那些引起杂合性丧失（LOH）的改变，最近被认为是一种新型的致癌机制，并且是许多恶性肿瘤的有用预后因素。但是，很少有研究集中在特定部位下咽。这项研究的目的是评估LOH与下咽鳞状细胞癌（HPSCC）之间的关系。研究设计：基于实验室的研究。单位：综合卫生保健系统。研究对象和方法：分别对30位HPSCC患​​者的正常和癌变组织的4个基因位点9p21、13q21、6q22和17p13的抑癌基因（TSG）（p16，Rb，E-cadherin和p53）的LOH进行了检查。 ，使用通过聚合酶链反应扩增的微卫星标记。将每个基因座的结果与临床病理特征进行比较。结果：30例患者中，有26例（86.7％）表现出LOH，最常见的改变是p53处的LOH（52.6％）。在淋巴结转移的情况下，Rb，p53和高LOH高组（发现2个或更多LOH基因座的情况）的LOH检测率明显更高。与I和II期癌症相比，Rb，p53和高LOH组的III和IV期肿瘤的LOH频率明显更高。但是，LOH的存在与生存没有显着相关。结论：这些结果表明，诸如Rb和p53的TSG中的LOH可能有助于HPSCC的发生和发展。原发性肿瘤中LOH的存在也可能预示着淋巴结转移。

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