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首页> 外文期刊>Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology >Analysis of hepatitis B virus in the cerumen and otorrhea of chronic HBV-infected patients: is there a hepatitis B virus infectivity?
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Analysis of hepatitis B virus in the cerumen and otorrhea of chronic HBV-infected patients: is there a hepatitis B virus infectivity?

机译：慢性HBV感染患者的子宫和耳漏中的乙型肝炎病毒分析：是否存在乙型肝炎病毒感染性？

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HYPOTHESIS: The object of this study was to find out whether cerumen and otorrhea have any infectivity in the transmission of hepatitis B virus (HBV). BACKGROUND: The HBV infection is a worldwide health problem. It can be transmitted by infected blood or other body fluids through percutaneous or permucosal exposure. Recently, there have been some reports where cerumen can be a potential source of HBV transmission. METHODS: This study was performed on 30 chronic hepatitis B patients who tested positive in hepatitis B surface antigen (HBs Ag). Thirty cerumen and 5 otorrhea samples were analyzed. The cerumen and the serum were examined for (HBs Ag) and hepatitis B e antigen (HBe Ag) by using enzyme immunoassay systems. As for HBV DNA detection, quantitative polymerase chain reaction was performed on the serum, cerumen, and otorrhea. RESULTS:: Hepatitis B virus DNA was detected in the 20 samples of cerumen (66.7%) and all 5 otorrhea (100%) from 30 patients. The mean values of HBV DNA in cerumen and otorrhea were significantly lower than serum. Hepatitis B virus DNA and HBs Ag were detected with significantly higher rates in the cerumen of patients who are serum HBe Ag positive than negative. However, positive HBe Ag, which implies that it is associated with the increased risk of disease progression and infectivity, was not detected in any of cerumen samples. CONCLUSION: The cerumen and otorrhea of chronic hepatitis B patients have a low risk of infectivity.
机译：假设：这项研究的目的是发现在C型肝炎病毒的传播过程中，宫颈和耳漏是否具有传染性。背景：HBV感染是全球性的健康问题。它可以通过经皮或粘膜暴露被感染的血液或其他体液传播。最近，有一些报道指出，陶瓷可能是乙肝病毒传播的潜在来源。方法：本研究是针对30名慢性乙型肝炎患者进行的，这些患者的乙型肝炎表面抗原（HBs Ag）检测阳性。分析了30个陶土和5个耳漏样品。通过使用酶免疫测定系统检查血清和血清中的（HBs Ag）和乙型肝炎e抗原（HBe Ag）。至于HBV DNA检测，对血清，陶瓷和耳漏进行了定量聚合酶链反应。结果：在30例患者的20份血清中检出了乙型肝炎病毒DNA（66.7％），所有5种耳漏检出了100％。血清和耳漏中HBV DNA的平均值显着低于血清。在血清HBe Ag阳性患者的血清中发现乙肝病毒DNA和HBs Ag的比率显着更高。但是，在任何陶瓷样品中都没有检测到阳性的HBe Ag，这暗示它与疾病进展和感染的风险增加有关。结论：慢性乙型肝炎患者的皮肤和耳漏感染风险较低。

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