...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Organic process research & development >Kinetics for scale-up of a one-pot pathway to 5-(3-fluorophenyl)-2 4-di hydro-2,4-dimethyl-3H-1,2,4-triazole-3-thione using a hybrid model of parallel and consecutive reactions
【24h】

Kinetics for scale-up of a one-pot pathway to 5-(3-fluorophenyl)-2 4-di hydro-2,4-dimethyl-3H-1,2,4-triazole-3-thione using a hybrid model of parallel and consecutive reactions

机译：一锅法合成5-（3-氟苯基）-2 4-二氢-2,4-二甲基-3H-1,2,4-三唑-3-硫酮的动力学的动力学模型平行和连续反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Kinetic results are reported for the one-pot reaction of 2,4-dimethylthiosemicarbazide (1) and 3-fluorobenzoyl chloride (2) to the unisolated benzamide intermediate (3), and on to the ring-closed product, 5-(3-fluorophenyl)-2,4-dihydro-2,4-dimethyl-3H-1,2,4-triazole-3-thione (4). The sensitivity of the synthetic route to competing side reactions was examined by studying the kinetics of each reaction step. A first-order kinetic Model of the hybrid consecutive and parallel reaction scheme was developed and fit to experimental data. The Model was extended to address potential mixing concerns resulting from the formation of the insoluble intermediate 3 upon scale-up where a more concentrated reaction would be used. Scale-up of the product drug substance from laboratory to 50-gal scale was successfully completed using this recently developed one-pot pathway.
机译：动力学结果报道了2,4-二甲基硫代氨基脲（1）和3-氟苯甲酰氯（2）与未分离的苯甲酰胺中间体（3）以及与闭环产物5-（3-氟苯基）-2,4-二氢-2,4-二甲基-3H-1,2,4-三唑-3-硫酮（4）。通过研究每个反应步骤的动力学，研究了合成路线对竞争性副反应的敏感性。建立了混合连续和平行反应方案的一阶动力学模型，并拟合实验数据。扩展了模型以解决潜在的混合问题，这些问题是由放大后形成不溶性中间体3引起的，其中将使用更浓缩的反应。使用这种最近开发的一锅法，成功地完成了将产品原料药从实验室规模扩大到50加仑的规模。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号