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首页> 外文期刊>Scandinavian journal of plastic and reconstructive surgery and hand surgery >Graft repair of a peripheral nerve without the sacrifice of a healthy donor nerve by the use of acutely dissociated autologous Schwann cells.
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Graft repair of a peripheral nerve without the sacrifice of a healthy donor nerve by the use of acutely dissociated autologous Schwann cells.

机译：通过使用急性分离的自体雪旺氏细胞，可以在不牺牲健康的供体神经的情况下进行周围神经的移植修复。

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摘要

We hypothesised that pieces of nerve that are normally trimmed away during graft repair could be a source of Schwann cells and used to create an autologous cell-containing nerve graft. To test the idea a transsection injury was made on the rat sciatic nerve. Seven days later, pieces from the proximal and distal stumps were used for immediate isolation of its non-neuronal cells. These cells, of which 80% were Schwann cells, were injected into a silicone tube bridging a 10 mm gap on the same nerve. Tubes containing cells showed superior regeneration of nerve fibres across the gap compared with tubes with no cells. This new repair technique is rapid, does not require the sacrifice of a healthy donor nerve, or the time-consuming culturing and expansion of Schwann cells. The method has the potential to replace current methods for repair of extended nerve injuries.
机译：我们假设在移植物修复过程中通常被修剪掉的神经碎片可能是雪旺细胞的来源，并被用于创建包含自体细胞的神经移植物。为了验证这一想法，对大鼠坐骨神经进行了横断损伤。 7天后，使用来自近端和远端残端的碎片立即分离其非神经元细胞。将这些细胞（其中80％是雪旺氏细胞）注入到一根硅胶管中，该硅胶管在同一条神经上桥接10毫米的间隙。与没有细胞的试管相比，含有细胞的试管显示出跨间隙的神经纤维具有更好的再生能力。这种新的修复技术是快速的，不需要牺牲健康的供体神经，也不需要费时的培养和扩增雪旺细胞。该方法有可能替代目前修复延伸神经损伤的方法。

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