An Improved Scalable Route to Pure Dronedarone Hydrochloride

Raghvendra R. Hivarekar; Sanjay S. Deshmukh; Narendra K. Tripathy

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An Improved Scalable Route to Pure Dronedarone Hydrochloride

机译：纯化的纯决奈达隆盐酸盐的改进的可扩展路线

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An efficient scalable synthesis for dronedarone hydrochloride (2) via Friedel-Craft acylation of 2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H)dione (12) with 4-(3-chIoropropoxy) benzoic acid (13) in good yield and high purity has been developed by using Eaton's reagent instead of hazardous and toxic metal halide catalyst like AlCl3 or SnCl4.

机译：通过2-（-2-丁基-1-苯并呋喃-5-基）-1H-异吲哚-1,3（2H）二酮（12）与4-的2-（-2-丁基-1-苯并呋喃-5-基）的Friedel-Craft酰化反应，有效地合成决奈达隆盐酸盐（2）通过使用伊顿试剂代替诸如AlCl3或SnCl4之类的有毒有毒金属卤化物催化剂，已经开发出了具有高收率和高纯度的（3-氯丙氧基）苯甲酸（13）。

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《Organic process research & development》 |2012年第4期|共5页
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Raghvendra R. Hivarekar; Sanjay S. Deshmukh; Narendra K. Tripathy;
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1. An Improved Scalable Route to Pure Dronedarone Hydrochloride [J] . Raghvendra R. Hivarekar, Sanjay S. Deshmukh, Narendra K. Tripathy Organic process research & development . 2012,第4期

机译：纯化的纯决奈达隆盐酸盐的改进的可扩展路线
2. An Improved and Efficient Process for the Production of Dronedarone Hydrochloride, an Antiarrhythmia Drug [J] . Anil C. Mali, Sharad S. Ippar, Mahendra B. Bodke Organic process research & development . 2013,第5期

机译：一种生产抗心律失常药物盐酸决奈达隆的改进高效方法
3. Expeditious novel routes to enantiopure 3-amino tetrahydrofuran hydrochloride [J] . Ramanujam R., Ganjihal S., Kalyanam N., Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry . 2013,第11期

机译：快速生成对映体纯的3-氨基四氢呋喃盐酸盐的新方法
4. TBRA: A Scalable Routing Algorithm in Highly Mobile Large Scale Pure Ad Hoc Wireless Mesh Networks [C] . Wei Ren, Yi Ren, Hui Zhang IEEE international conference on computer science and information technology;ICCSIT 2009 . 2009

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5. Effects of ractopamine hydrochloride are not confined to mammalian tissue: Evidence for direct effects of ractopamine hydrochloride supplementation on fermentation by ruminal microorganisms. [D] . Walker, Callie Elizabeth. 2009

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7. Scale-up Synthesis of (R)- and (S)N(2-Benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide Hydrochloride, A Versatile Reagent for the Preparation of Tailor-Made - and Amino Acids in an Enantiomerically Pure Form [O] . -1

机译：（R） - 和（S）N（2-苯甲酰基-4-氯苯基）-1-（3,4-二氯苄基）吡咯烷-2-甲酰胺盐酸盐，盐酸吡咯烷-2-甲酰胺，用于制备量身定制的 - 纯纯形式的氨基酸

An Improved Scalable Route to Pure Dronedarone Hydrochloride

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