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首页> 外文期刊>Organic process research & development >The Importance of Acetonitrile in the Pharmaceutical Industry and Opportunities for its Recovery from Waste
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The Importance of Acetonitrile in the Pharmaceutical Industry and Opportunities for its Recovery from Waste

机译：乙腈在制药工业中的重要性及其从废物中回收的机会

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Acetonitrile is regarded as a key solvent in the pharmaceutical industry. However, the volatility in acetonitrile supply in recent years, coupled with its relatively poor environmental profile, has presented significant challenges to its use in manufacturing processes and laboratories. This study investigates the importance of acetonitrile in the pharmaceutical industry and critically examines several options for reducing the exposure of the industry to future supply problems whilst also improving its life cycle management. The physicochemical properties of acetonitrile were compared with other typical process solvents and the Conductor-like Screening. Model (COSMO) surfaces and sigma profiles were used to help explain the favorable solvation behaviour of acetonitrile. Several options for the replacement or recovery and recycle of acetonitrile were critically examined in the contexts of environmental, technical, and economic feasibility. Azeotropic distillation was found to be the most likely approach to recovering acetonitrile from aqueous waste streams. Several potential breaking agents were assessed against a range of selection rules based on residue curve maps, determined using the Universal Functional Activity Coefficient (UNIFAC) method, and potential processing issues. A range of ionic liquids were screened via the predictive Conductor-like Screening Model for Realistic Solvation (COSMO-RS) approach and several promising candidates were identified. Experimental vapor-liquid equilibria studies were carried out, confirming the feasibility of ionic liquid-enhanced azeotropic distillation as a novel approach to acetonitrile recovery.
机译：乙腈被认为是制药行业的关键溶剂。然而，近年来乙腈供应的波动性以及相对较差的环境状况，对其在生产过程和实验室中的使用提出了巨大的挑战。这项研究调查了乙腈在制药行业中的重要性，并严格审查了几种选择方案，以减少该行业对未来供应问题的接触，同时还改善其生命周期管理。将乙腈的理化性质与其他典型的工艺溶剂和类似导体的屏蔽剂进行了比较。使用模型（COSMO）表面和sigma轮廓帮助解释乙腈的良好溶剂化行为。在环境，技术和经济可行性的背景下，对替代或回收乙腈的几种选择进行了严格审查。发现共沸蒸馏是从含水废物流中回收乙腈的最可能方法。根据残基曲线图（使用通用功能活性系数（UNIFAC）方法确定）和潜在的加工问题，针对一系列选择规则对几种潜在的破坏剂进行了评估。通过预测性的类似溶剂的逼真的溶剂筛选模型（COSMO-RS）方法筛选了一系列离子液体，并确定了一些有希望的候选物。进行了实验性的气液平衡研究，证实了离子液体增强共沸蒸馏作为乙腈回收的新方法的可行性。

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