Expression pattern of cathepsin W isoforms in peripheral blood and gastroesophageal mucosa of patients with gastroesophageal reflux disease.

Raab AK; Monkemuller K; Kandulski A; Weber E; Malfertheiner P; Wex T

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Expression pattern of cathepsin W isoforms in peripheral blood and gastroesophageal mucosa of patients with gastroesophageal reflux disease.

机译：组织蛋白酶W同工型在胃食管反流病患者外周血和胃食管粘膜中的表达模式。

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Cathepsin W is exclusively expressed in immune cells, and a novel isoform was identified previously. To characterize the expression pattern of the wildtype and isoform Ins10, specific polymerase chain reaction assays were generated and used to study respective transcript levels in peripheral blood cells and gastric biopsies in healthy subjects. The wildtype-encoding transcript levels were 3- and 9-fold higher in mucosal samples and peripheral immune cells, respectively (p<0.05). The predominant expression of wildtype form by infiltrating immune cells was confirmed in 116 patients with gastroesophageal reflux disease and 27 reflux-negative individuals demonstrating that cathepsin W expression is not altered in this disease.

机译：组织蛋白酶W仅在免疫细胞中表达，并且先前已鉴定出新的同种型。为了表征野生型和同工型Ins10的表达模式，生成了特定的聚合酶链反应测定法，并用于研究健康受试者外周血细胞和胃活检中各自的转录水平。在粘膜样品和外周免疫细胞中，野生型编码的转录水平分别提高了3倍和9倍（p <0.05）。在116例胃食管反流病患者和27例反流阴性患者中证实了通过浸润免疫细胞主要表达野生型的现象，这表明组织蛋白酶W的表达在这种疾病中没有改变。

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《Biological chemistry》 |2011年第12期|共6页
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Raab AK; Monkemuller K; Kandulski A; Weber E; Malfertheiner P; Wex T;
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1. Expression pattern of cathepsin W isoforms in peripheral blood and gastroesophageal mucosa of patients with gastroesophageal reflux disease. [J] . Raab AK, Monkemuller K, Kandulski A, Biological chemistry . 2011,第12期

机译：组织蛋白酶W同工型在胃食管反流病患者外周血和胃食管粘膜中的表达模式。
2. Zonulin is not increased in the cardiac and esophageal mucosa of patients with gastroesophageal reflux disease. [J] . Wex T, Monkemuller K, Kuester D Peptides: An International Journal . 2009,第6期

机译：胃食管反流病患者的心脏和食管粘膜中的结合蛋白未增加。
3. Treatment patterns in paediatric patients with a new diagnosis of gastroesophageal reflux disease. [J] . Ruigomez A, Hungin AP, Lundborg P, European journal of gastroenterology and hepatology . 2011,第3期

机译：新诊断为胃食管反流病的小儿患者的治疗方式。
4. A Multi-Parametric System for Gastroesophageal Reflux Disease Diagnosis in Newborn Patients [C] . A. Barriga-Rivera, M. J. Moya-Jimenez, M. Elena Perez, World Congress on Medical Physics and Biomedical Engineering . 2013

机译：新生儿患者胃食管反流疾病诊断的多参数系统
5. Prospective evaluation of serum vitamin B12 levels in patients receiving long-term lansoprazole for gastroesophageal reflux disease. [D] . Sotiriou, Christopher Gus. 2000

机译：长期接受兰索拉唑治疗胃食管反流病患者的血清维生素B12水平的前瞻性评估。
6. Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastroesophageal reflux disease. [O] . S Oberg, J H Peters, T R DeMeester, 1997

机译：心脏粘膜的炎症和特殊的肠上皮化生是胃食管反流疾病的一种表现。
7. Avaliação dos danos do DNA na mucosa esofágica e sangue periférico de portadores da doença do refluxo gastroesofágico Evaluation of DNA damage in the esophageal mucosa and peripheral blood of patients with gastroesophageal reflux disease [O] . Edilene Lúcia Bertolozzo, Dertia Villalba Freire-Maia, Mauro Masson Lerco, 2010

机译：胃食管反流病患者食管黏膜和外周血DNa损伤的评估胃食管反流病患者食管黏膜和外周血DNa损伤的评估
8. Gastroesophageal Reflux (GER) and Gastroesophageal Reflux Disease (GERD) in Adults. [R] . 2014

机译：成人胃食管反流（GER）和胃食管反流病（GERD）。

Expression pattern of cathepsin W isoforms in peripheral blood and gastroesophageal mucosa of patients with gastroesophageal reflux disease.

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