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首页> 外文期刊>Cell and tissue banking: An international journal of banking, engineering & transplantation of cells and tissues >Chondrogenic capability of osteoarthritic chondrocytes from the trapeziometacarpal and hip joints
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Chondrogenic capability of osteoarthritic chondrocytes from the trapeziometacarpal and hip joints

机译：掌骨和髋关节的骨关节炎软骨细胞的成软骨能力

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摘要

Osteoarthritis is the most common degenerative disease of joints like the hip and the trapeziometacarpal joint (rhizarthrosis). In this in vitro study, we compared the chondrogenesis of chondrocytes derived from the trapezium and the femoral head cartilage of osteoarthritic patients to have a deeper insight on trapezium chondrocyte behavior as autologous cell source for the repair of cartilage lesions in rhizarthrosis. Chondrocytes collected from trapezium and femoral head articular cartilage were cultured in pellets and analyzed for chondrogenic differentiation, cell proliferation, glycosaminoglycan production, gene expression of chondrogenic and fibrous markers, histological and immunohistochemical analyses. Our results showed a higher cartilaginous matrix deposition and a lower fibrocartilaginous phenotype of the femoral chondrocytes with respect to the trapezium chondrocytes assessed by a higher absolute glycosaminoglycan and type II collagen production, thus demonstrating a superior chondrogenic potential of the femoral with respect to the trapezium chondrocytes. The differences in chondrogenic potential between trapezium and femoral head chondrocytes confirmed a lower regenerative capability in the trapezium than in the femoral head cartilage due to the different environment and loading acting on these joints that affects the metabolism of the resident cells. This could represent a limitation to apply the cell therapy for rhizoarthrosis.
机译：骨关节炎是最常见的关节退行性疾病，例如髋关节和斜方腕关节（棘皮症）。在这项体外研究中，我们比较了梯形软骨细胞和骨关节炎患者股骨头软骨的软骨形成，以了解梯形软骨细胞作为自体细胞来源修复软骨性软骨病的行为。收集从梯形和股骨头关节软骨收集的软骨细胞，并进行软骨形成分化，细胞增殖，糖胺聚糖的产生，软骨和纤维标记物的基因表达，组织学和免疫组织化学分析。我们的结果表明，相对于梯形软骨细胞，股骨软骨细胞具有较高的软骨基质沉积和较低的纤维软骨表型。 。梯形和股骨头软骨细胞之间的软骨形成电位差异证实，由于环境和作用在这些关节上的负荷不同，梯形的再生能力低于股骨头软骨，从而影响了驻留细胞的代谢。这可能代表了将细胞疗法应用于根际关节炎的局限性。

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