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首页> 外文期刊>Molecular Microbiology >The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteers.
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The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteers.

机译：淋球菌FA1090株表达的转铁蛋白受体是人类男性志愿者实验感染所必需的。

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摘要

Iron, an essential nutrient for most microorganisms, is sequestered by the host to decrease the concentration of iron available to bacterial pathogens. Neisseria gonorrhoeae, the causative agent of gonorrhoea, can acquire iron by direct interaction with human iron-binding proteins, including the serum glycoprotein, transferrin. Iron internalization from host transferrin requires the expression of a bacterial receptor, which specifically recognizes the human form of transferrin. Two gonococcal transferrin-binding proteins have been implicated in transferrin receptor function, TbpA and TbpB. We constructed a gonococcal transferrin receptor mutant without the introduction of additional antibiotic resistance markers and tested its ability to cause experimental urethritis in human male volunteers. The transferrin receptor mutant was incapable of initiating urethritis, although the same inoculum size of the wild-type parent strain, FA1090, causes urethritis in >90% of inoculated volunteers. To our knowledge, this is the first experimental demonstration that a bacterial iron acquisition system is an essential virulence factor for human infection.
机译：铁是大多数微生物必需的营养素，被宿主隔离，以降低细菌病原体可利用的铁浓度。淋病奈瑟氏球菌是淋病的病原体，可通过与人铁结合蛋白（包括血清糖蛋白，转铁蛋白）直接相互作用而获得铁。宿主运铁蛋白的铁内在化需要细菌受体的表达，该受体特异性识别人形式的运铁蛋白。两种淋球菌转铁蛋白结合蛋白与转铁蛋白受体功能有关，即TbpA和TbpB。我们构建了一个淋球菌转铁蛋白受体突变体，未引入其他抗生素抗性标记，并测试了其在人类男性志愿者中引起实验性尿道炎的能力。转铁蛋白受体突变体无法引发尿道炎，尽管野生型亲本菌株FA1090的相同接种量会在90％以上的被接种志愿者中引起尿道炎。据我们所知，这是细菌铁捕获系统是人类感染必不可少的毒力因子的第一个实验证明。

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