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首页> 外文期刊>Scandinavian journal of clinical and laboratory investigation. >Increased urinary orosomucoid excretion: a proposed marker for inflammation and endothelial dysfunction in patients with type 2 diabetes.
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Increased urinary orosomucoid excretion: a proposed marker for inflammation and endothelial dysfunction in patients with type 2 diabetes.

机译：尿类类固醇分泌增加：是2型糖尿病患者炎症和内皮功能障碍的拟议标志物。

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OBJECTIVE: In a previous study, urinary orosomucoid excretion rate (UOER) independently predicted cardiovascular mortality in patients with type 2 diabetes. The aim of the present study was to determine whether increased UOER is associated with cardiovascular risk factors such as inflammation, impaired left ventricular function and endothelial dysfunction in patients with type 2 diabetes. MATERIAL AND METHODS: We performed a cross-sectional study of 41 patients with type 2 diabetes (17 patients with normal UOER and 24 with increased UOER) with no history of cardiovascular disease and 21 healthy controls. Urinary orosomucoid was measured using a particle-enhanced immunoturbidimetric assay. Plasma interleukin-6 (IL-6), tissue plasminogen activator (tPA) and soluble intercellular adhesion molecule-1 (sICAM) were measured using ELISA. Endothelial function measured as vasodilatory capacity of the brachial artery and echocardiography were done in all participants. RESULTS: Patients with diabetes and increased UOER had subclinically increased serum orosomucoid (p<0.001), C-reactive protein (CRP) (p<0.001), IL-6 (p<0.001), tPA (p<0.003) and sICAM (p<0.003) compared with healthy controls. In patients with type 2 diabetes, UOER was independently associated with increasing values of IL-6 (1.43 (1.06-1.93)) and tPA (1.82 (1.20-2.77)). Measurements by echocardiography showed no signs of cardiac dysfunction. CONCLUSIONS: Asymptomatic patients with type 2 diabetes and increased UOER displayed signs of chronic low-grade inflammation and endothelial dysfunction. UOER was independently related to markers of proinflammation and endothelial dysfunction in patients with type 2 diabetes. The previously shown relation between increased UOER and cardiovascular mortality is proposed to be caused by chronic low-grade inflammation and early endothelial dysfunction.
机译：目的：在先前的研究中，尿中类类固醇的排泄率（UOER）独立预测2型糖尿病患者的心血管死亡率。本研究的目的是确定2型糖尿病患者的UOER升高是否与心血管危险因素有关，例如炎症，左心室功能受损和内皮功能障碍。材料和方法：我们进行了一项横断面研究，涉及41例2型糖尿病患者（17例UOER正常，而24例UOER升高），无心血管疾病史和21名健康对照。使用颗粒增强免疫比浊法测定尿中类类固醇。使用ELISA测量血浆白细胞介素6（IL-6），组织纤溶酶原激活物（tPA）和可溶性细胞间黏附分子1（sICAM）。在所有参与者中测量以肱动脉血管舒张能力和超声心动图测量的内皮功能。结果：糖尿病和UOER升高的患者亚临床上血清类类固醇（p <0.001），C反应蛋白（CRP）（p <0.001），IL-6（p <0.001），tPA（p <0.003）和sICAM（临床上增加）与健康对照组相比p <0.003）。在2型糖尿病患者中，UOER独立地与IL-6（1.43（1.06-1.93））和tPA（1.82（1.20-2.77））升高有关。超声心动图的测量结果显示没有心脏功能障碍的迹象。结论：无症状的2型糖尿病和UOER升高的患者表现出慢性低度炎症和内皮功能障碍的迹象。在2型糖尿病患者中，UOER与炎症和内皮功能障碍的标志物独立相关。先前显示的UOER升高与心血管疾病死亡率之间的关系被认为是由慢性低度炎症和早期内皮功能障碍引起的。

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