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首页> 外文期刊>Scandinavian journal of clinical and laboratory investigation. >Elevated visfatin levels in overweight and obese children and adolescents with metabolic syndrome.
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Elevated visfatin levels in overweight and obese children and adolescents with metabolic syndrome.

机译：超重和肥胖的儿童和青少年代谢综合征中的visfatin水平升高。

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OBJECTIVE: Adipokines have been implicated in the pathogenesis of metabolic syndrome (MetS) and insulin resistance. We investigated the association between these conditions and serum levels of visfatin, adiponectin and leptin. MATERIAL AND METHODS: 175 overweight and obese boys and girls aged 3-17 years. MetS was defined as presence of at least three of the following: triglycerides >or= 1.24 mmol/L, high-density lipoprotein cholesterol or= 6.1 mmol/L, elevated waist circumference and systolic or diastolic blood pressure >or= 90th percentile. RESULTS: After adjustment for age and gender visfatin levels were significantly higher (median 19.0 [25th, 75th percentiles 11.9 , 37.1] vs. 15.2 [11.6 , 21.1] ng/ml; p(adjusted) = 0.02) in subjects with MetS (n = 41) compared to subjects without (n = 134). There were no significant differences in adiponectin or leptin levels between the two groups after adjustment for age and gender. Visfatin levels increased proportionally with number of MetS components (beta = 0.16, 95%CI 0.04, 0.28; p(adjusted) = 0.01), and adiponectin levels decreased proportionally with number of components (beta = -0.11, 95%CI -0.18, -0.04; p(adjusted) = 0.002). Leptin levels were not related to number of components of MetS. Unlike visfatin, both adiponectin (beta = -0.24, 95%CI -0.33, -0.15; p adjusted < 0.001) and leptin (beta = 0.14, 95%CI 0.01, 0.28; p adjusted = 0.03) were associated with insulin resistance. CONCLUSION: The elevation of visfatin observed in children and adolescents with MetS was proportionate to number of components of MetS but was not associated with insulin resistance. The increase in visfatin may contribute to low-grade systemic inflammation associated with MetS.
机译：目的：脂肪因子已参与代谢综合征（MetS）和胰岛素抵抗的发病机制。我们调查了这些条件与visfatin，脂联素和瘦素的血清水平之间的关联。材料与方法：175名3-17岁的超重和肥胖男孩和女孩。 MetS被定义为存在以下至少三种：甘油三酸酯>或= 1.24 mmol / L，高密度脂蛋白胆固醇<或= 1.03 mmol / L，空腹血糖>或= 6.1 mmol / L，腰围和收缩压升高或舒张压>或= 90％。结果：调整年龄和性别后，在MetS（n）患者中，visfatin水平显着更高（中位值为19.0 [25、75％11.9，37.1] vs 15.2 [11.6，21.1] ng / ml; p（已调整）= 0.02） = 41），而没有（n = 134）。调整年龄和性别后，两组之间脂联素或瘦素水平无显着差异。 visfatin水平与MetS组分数量成正比增加（beta = 0.16，95％CI 0.04，0.28; p（已调整）= 0.01），脂联素水平与组分数量成比例下降（beta = -0.11，95％CI -0.18， -0.04; p（已调整）= 0.002）。瘦素水平与MetS的成分数量无关。与visfatin不同，脂联素（β= -0.24，95％CI -0.33，-0.15; p调整为<0.001）和瘦素（β= 0.14，95％CI 0.01，0.28; p调整为0.03）均与胰岛素抵抗相关。结论：在儿童和青少年MetS中观察到的visfatin升高与MetS的成分数量成正比，但与胰岛素抵抗无关。 visfatin的增加可能导致与MetS相关的轻度全身性炎症。

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