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首页> 外文期刊>Scandinavian journal of clinical and laboratory investigation. >Evaluation of reference intervals for biomarkers sensitive to alcohol consumption, excess body weight and oxidative stress.
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Evaluation of reference intervals for biomarkers sensitive to alcohol consumption, excess body weight and oxidative stress.

机译：评估对酒精消耗，体重过重和氧化应激敏感的生物标志物的参考间隔。

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BACKGROUND: Unexplained liver enzyme activities are often found in health screening programs and constitute an increasingly common cause for referral to specialized clinics. Recent studies have indicated that both excess body weight and alcohol consumption may lead to metabolic aberrations which are readily reflected in the activities of liver enzymes in circulation. MATERIALS AND METHODS: We compared various laboratory markers and their upper normal limits in relation to information on alcohol consumption and BMI in a large population of apparently healthy individuals collected from Nordic countries. RESULTS: Based on the data obtained from normal weight abstainers (BMI 19-25 kg/m(2)) the upper normal limits in men should be 50 U/L for ALT, and 45 U/L (<40 years) and 70 U/L (>or=40 years) for GGT, while the current recommendations are 70 U/L, 80 U/L, and 115 U/L, respectively. Already in comparisons between normal weight abstainers and corresponding moderate drinkers notable impacts (+14% - +74%) on upper limits for these analytes were seen, which further grew when adiposity occurred together with alcohol drinking (+75% - +186%, BMI >or=27 kg/m(2)). In addition to liver enzymes, similar changes were also found for uric acid. CONCLUSIONS: Alcohol consumption and excess body weight even in apparently healthy individuals have a significant influence on liver enzyme activities, which may be due to a cumulative oxidative stress burden. The metabolic changes induced by adiposity or ethanol intake should be considered in the definition of normal ranges for all laboratory parameters sensitive to oxidative stress.
机译：背景：无法解释的肝酶活性经常在健康检查程序中发现，并成为转诊至专门诊所的越来越普遍的原因。最近的研究表明，超重和饮酒都可能导致代谢异常，这很容易反映在循环中肝酶的活动中。材料与方法：我们比较了从北欧国家收集的大量显然健康的个体中与酒精摄入和BMI信息相关的各种实验室标记及其正常上限。结果：根据正常体重戒酒者（体重指数19-25 kg / m（2））获得的数据，男性的正常最高上限应为ALT为50 U / L，ALT为45 U / L（<40岁）和70 GGT的U / L（≥40年），而当前建议分别为70 U / L，80 U / L和115 U / L。在正常体重戒酒者和相应的中度饮酒者之间的比较中，已经发现这些分析物的上限有显着影响（+ 14％-+ 74％），当肥胖和饮酒一起发生时（+ 75％-+ 186％， BMI≥27 kg / m（2））。除肝酶外，尿酸也有类似变化。结论：即使在表面健康的人中，饮酒和超重对肝酶活性也有重要影响，这可能是由于累积的氧化应激负担所致。对于所有对氧化应激敏感的实验室参数，在正常范围的定义中应考虑由肥胖或乙醇摄入引起的代谢变化。

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