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首页> 外文期刊>Scandinavian journal of infectious diseases. >Diagnostic markers and risk factors of cytomegalovirus infection and disease in renal allograft recipients.
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Diagnostic markers and risk factors of cytomegalovirus infection and disease in renal allograft recipients.

机译：肾同种异体移植受者巨细胞病毒感染和疾病的诊断标志物和危险因素。

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In a prospective study, the incidences of CMV infection and disease were 56 and 23%, respectively, during the first 6 months following kidney transplantation. Viremia was found in all patients with CMV disease and arthralgia was present in 71% prior to the development of CMV disease. The positive predictive value for CMV disease reached up to 90% for viremia and arthralgia in combination. Viruria was poorly correlated to viremia and hence CMV disease. The majority of patients (93%) who developed CMV disease had a seropositive donor, and viremia was significantly more common in patients who received CMV-seropositive kidneys. CMV disease was more common in CMV-seronegative recipients than in seropositive recipients. The 1-year graft survival rate was 75% in the entire study group. In patients with CMV viremia and disease, the rates were 78 and 73%, respectively. Antiviral treatment was initiated within 3 weeks of viremia detection in the 6 patients with CMV disease who survived. We found that the combination of arthralgia and viremia was a useful predictor of CMV disease and that recipients of CMV-seropositive allografts were at a greater risk of developing CMV disease. To obtain an early diagnosis and commence an early treatment of CMV disease, patients prone to develop CMV disease should be identified and clinical examination and viremia surveillance should be performed regularly.
机译：在一项前瞻性研究中，在肾脏移植后的前6个月，CMV感染和疾病的发生率分别为56％和23％。在所有CMV疾病患者中均发现病毒血症，在CMV疾病发生之前，有71％的患者存在关节痛。 CMV疾病对病毒血症和关节痛的综合阳性预测价值高达90％。病毒血症与病毒血症以及因此与CMV疾病的相关性很差。发生CMV疾病的大多数患者（93％）具有血清反应阳性的供体，而接受CMV血清反应阳性的肾脏的患者中病毒血症更为常见。在CMV血清阴性患者中，CMV疾病比血清阳性患者更常见。在整个研究组中，一年移植物存活率为75％。在CMV病毒血症和疾病患者中，发生率分别为78％和73％。在幸存的6例CMV病患者中，在病毒血症检测后3周内开始了抗病毒治疗。我们发现，关节痛和病毒血症的组合是CMV疾病的有用预测指标，而接受CMV血清阳性的同种异体移植患者发生CMV疾病的风险更大。为了获得早期诊断并开始对CMV疾病的早期治疗，应确定易患CMV疾病的患者，并应定期进行临床检查和病毒血症监测。

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