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首页> 外文期刊>Scandinavian journal of infectious diseases. >A prospective, randomized, multicenter comparative study of clinafloxacin versus a ceftriaxone-based regimen in the treatment of hospitalized patients with community-acquired pneumonia.
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A prospective, randomized, multicenter comparative study of clinafloxacin versus a ceftriaxone-based regimen in the treatment of hospitalized patients with community-acquired pneumonia.

机译：克林沙星与以头孢曲松为基础的方案治疗社区获得性肺炎住院患者的前瞻性，随机，多中心比较研究。

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摘要

In an open-label, phase 3, randomized, multicenter study, clinafloxacin (200 mg/d) was compared to ceftriaxone (2 g/d; with or without erythromycin) in 527 patients with acute community-acquired bacterial pneumonia (CAP). Primary efficacy parameters were clinical cure rate and microbiologic eradication rates (by pathogen and by patient) determined 5-9 d post-therapy (test of cure; TOC). Clinical cure rates at TOC for the 2 treatment groups were equivalent in the intention-to-treat (clinafloxacin 79.3, ceftriaxone 78.6%), clinically evaluable (clinafloxacin 88.1, ceftriaxone 85.0%), modified intention-to-treat (clinafloxacin 82.6, ceftriaxone 86.9%) and microbiologically evaluable populations (clinafloxacin 86.2, ceftriaxone 86.2%). Microbiologic eradication rates were similar in the 2 treatment groups. Both drugs were tolerated. Treatment of hospitalized CAP patients with clinafloxacin is a reasonable choice, especially when a resistant pathogen is anticipated.
机译：在一项开放式标签，第3期，随机，多中心研究中，比较了527例急性社区获得性细菌性肺炎（CAP）患者中的clinafloxacin（200 mg / d）与头孢曲松钠（2 g / d;有或没有红霉素）的比较。主要功效参数是治疗后5-9 d（治愈测试; TOC）确定的临床治愈率和微生物根除率（按病原体和患者划分）。 2个治疗组在TOC上的临床治愈率在意向治疗（克立那沙星79.3，头孢曲松钠78.6％），临床可评估（克林沙星88.1，头孢曲松85.0％），改良意向治疗（克林沙星82.6，头孢曲松86.9％）和具有微生物学评估的人群（克林沙星86.2，头孢曲松86.2％）。在两个治疗组中，微生物根除率相似。两种药物都可以耐受。用克林沙星治疗住院的CAP患者是一个合理的选择，尤其是在预期有耐药菌的情况下。

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