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首页> 外文期刊>Cardiovascular engineering and technology >Optimization of Oxygen Delivery in Fluid Resuscitation for Hemorrhagic Shock: A Computer Simulation Study
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Optimization of Oxygen Delivery in Fluid Resuscitation for Hemorrhagic Shock: A Computer Simulation Study

机译：失血性休克液体复苏中氧气输送的优化：计算机模拟研究

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The main objective of fluid resuscitation in hemorrhage induced hypovolemia is to increase oxygen delivery to vital organs and to restore other hemodynamic variables to acceptable physiological range. Since replacement of blood with fluid causes both increase in cardiac output and decrease in the plasma oxygen carrying unit concentration, there is an overall opposing effect on total oxygen delivery rate to tissue. Thus, optimal fluid infusion rate and volume may be expected. The purpose of this study was to study the temporal dynamics of oxygen delivery rate during fluid replacement in a controlled hemorrhage scenario and seek these optimal values. A hemodynamic model of the human adult cardiovascular system was developed to simulate and evaluate arterial oxygen delivery at normal and at hemorrhagic conditions in different fluid resuscitation regimes. The results demonstrated the existence of a unique optimal fluid replacement regimen for maximal oxygen delivery rate at different controlled bleeding scenarios. The maintenance of high oxygen delivery rate was better with lower fluid infusion rates. The model results indicate that hematocrit and mean arterial pressure can be used to determine the optimal infusion rate and fluid infusion endpoint in fluid resuscitation.
机译：出血引起的血容量不足的液体复苏的主要目的是增加向重要器官的氧气输送，并将其他血液动力学变量恢复到可接受的生理范围。由于用液体代替血液会导致心输出量的增加和血浆氧携带单位浓度的降低，因此总体上对组织的氧气输送速率存在相反的影响。因此，可以期望最佳的输液速度和体积。这项研究的目的是研究在控制性出血情况下补液期间氧气输送速率的时间动态，并寻求这些最佳值。开发了人类成人心血管系统的血液动力学模型，以模拟和评估在不同液体复苏方案下正常和出血情况下的动脉氧气输送。结果表明，在不同的控制出血情况下，最大的氧气输送速率存在独特的最佳液体替代方案。较低的输液速度可保持较高的氧气输送速度。该模型结果表明，血细胞比容和平均动脉压可用于确定液体复苏中的最佳输注速率和输液终点。

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