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首页> 外文期刊>Cerebral cortex >Dissociating the roles of right ventral lateral and dorsal lateral prefrontal cortex in generation and maintenance of hypotheses in set-shift problems.
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Dissociating the roles of right ventral lateral and dorsal lateral prefrontal cortex in generation and maintenance of hypotheses in set-shift problems.

机译：分离右腹外侧和背外侧前额叶皮层在定班问题中的假设的产生和维持中的作用。

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Although patient data have traditionally implicated the left prefrontal cortex (PFC) in hypothesis generation, recent lesion data implicate right PFC in hypothesis generation tasks that involve set shifts (lateral transformations). To test the involvement of the right prefrontal cortex in a hypothesis generation task involving set shifts, we scanned 13 normal subjects with fMRI as they completed Match Problems (a classic divergent thinking task) and a baseline task. In Match Problems subjects determined the number of possible solutions for each trial. Successful solutions are indicative of set shifts. In the baseline condition subjects evaluated the accuracy of hypothetical solutions to match problems. A comparison of Match Problems versus baseline trials revealed activation in right ventral lateral PFC (BA 47) and left dorsal lateral PFC (BA 46). A further comparison of successfully versus unsuccessfully completed Match Problems revealed activation in right ventral lateral PFC (BA 47), left middle frontal gyrus (BA 9) and left frontal pole (BA 10), thus identifying the former as a critical component of the neural mechanisms of set-shift transformation. By contrast, activation in right dorsal lateral PFC (BA 46) covaried as a function of the number of solutions generated in Match Problems, possibly due to increased working memory demands to maintain multiple solutions 'on-line', conflict resolution, or progress monitoring. These results go beyond the patient data by identifying the ventral lateral (BA 47) aspect of right PFC as being a critical component of the neural systems underlying lateral transformations, and demonstrate a dissociation between right VLPFC and DLPFC in hypotheses generation and maintenance.
机译：尽管患者数据传统上牵涉到假说生成中的左前额叶皮层（PFC），但是最近的病灶数据暗示着右PFC参与了涉及设定移位（横向转换）的假说生成任务。为了测试右前额叶皮层是否参与涉及设定移位的假设生成任务，我们在完成匹配问题（经典发散思维任务）和基线任务的13名正常受试者中进行了功能磁共振成像扫描。在“比赛问题”中，受试者确定了每个试验的可能解决方案的数量。成功的解决方案表明了设定的转变。在基线条件下，受试者评估了假设解决方案匹配问题的准确性。匹配问题与基线试验的比较显示，右腹外侧PFC（BA 47）和左背外侧PFC（BA 46）处于激活状态。对成功与未成功完成的匹配问题的进一步比较显示，右腹外侧PFC（BA 47），左中额回（BA 9）和左额极（BA 10）被激活，因此确定前者是神经的重要组成部分集移变换的机制。相比之下，右背外侧PFC（BA 46）的激活随“匹配问题”中生成的解决方案数量而变化，这可能是由于维护“在线”多个解决方案，冲突解决方案或进度监控所需的工作记忆增加。通过确定右PFC的腹侧（BA 47）方面是侧向转换背后的神经系统的关键组成部分，这些结果超出了患者数据，并证明了假说的产生和维持中右VLPFC和DLPFC之间的分离。

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