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首页> 外文期刊>Sensors and Actuators, A. Physical >A pulsed wave excitation system to characterize micron-scale magnetoelastic biosensors
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A pulsed wave excitation system to characterize micron-scale magnetoelastic biosensors

机译：用于表征微米级磁弹性生物传感器的脉冲激励系统

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摘要

This paper describes the design of a resonant frequency measurement system based on a pulsed wave excitation technique that can be used to resonate and measure micron-size Magnetoelastic (ME) biosensors. Current measurement techniques can only detect millimeter and above size ME biosensors. By using a specially designed, dedicated coil and low noise cascade amplifier, the system described in this paper is capable of measuring micron-size (ME) biosensors as small as 200 (im in length (200× 40× 15 μm). In the system, a square pulse current is applied to an excitation coil to excite the ME sensors, and a pick-up coil senses its mechanical vibration and converts it to an electrical output signal. The output signal is amplified by a signal amplification circuit and the output waveform is shown on an oscilloscope. Based on the acquired damped oscillating signal, the frequency change due to the mass change on the surface of the ME biosensor can be calculated. The impact of signal amplification on the resonant frequency, amplitude, and Q-factor of the resonant frequency peak, has been studied. The average resonant frequency of a 200 μm sensor was found to be 10.8283 ±0.0027 MHz. As a proof-in-concept experiment, the detection system was used in combination with JRB7 phage-coated ME biosensors to detect different concentrations of Bacillus anthracis spores. A statistically significant difference for all concentrations of 5 × 10~2 spore/ml and higher can be reached by the system.
机译：本文介绍了一种基于脉冲波激励技术的谐振频率测量系统的设计，该系统可用于谐振和测量微米尺寸的磁弹性（ME）生物传感器。当前的测量技术只能检测毫米以上的ME生物传感器。通过使用经过特殊设计的专用线圈和低噪声级联放大器，本文描述的系统能够测量小至200（微米长度（200×40×15μm））的微米尺寸（ME）生物传感器。在系统中，将方形脉冲电流施加到励磁线圈上，以激励ME传感器，而拾波线圈则感测其机械振动并将其转换为电输出信号，该输出信号由信号放大电路放大，然后输出波形显示在示波器上，根据获取的阻尼振荡信号，可以计算出ME生物传感器表面质量变化引起的频率变化，信号放大对谐振频率，幅度和Q因子的影响研究了共振频率峰值的变化，发现200μm传感器的平均共振频率为10.8283±0.0027 MHz，作为概念验证实验，将检测系统与JRB7噬菌体涂层结合使用ME生物传感器可检测不同浓度的炭疽芽孢杆菌孢子。系统可以达到所有浓度为5×10〜2孢子/ ml和更高的统计学显着性差异。

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