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首页> 外文期刊>Seminars in Gastrointestinal Disease >Supraesophageal manifestations of gastroesophageal reflux disease.
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Supraesophageal manifestations of gastroesophageal reflux disease.

机译：胃食管反流病的食管上表现。

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An increasing amount of evidence indicates that gastroesophageal reflux disease (GERD) is a contributing factor to hoarseness, throat clearing, throat discomfort, chronic cough, and shortness of breath. The association between GERD and these supraesophageal symptoms may be elusive. Heartburn and regurgitation are absent in more than 50% of patients. Acid reflux should be considered if signs of GERD are present, symptoms are unexplained, or symptoms are refractory to therapy. The diagnosis of GERD may be unclear, despite a careful history and initial evaluation. A high index of suspicion is required to make the diagnosis. An empiric trial of antireflux therapy is appropriate when GERD is suspected. Multiprobe ambulatory pH monitoring is currently the diagnostic test of choice, but the level of sensitivity and specificity for supraesophageal manifestations of GERD is uncertain. Response to antireflux therapy is less predictable than typical GERD. More intensive acid suppression and longer treatment duration are usually required.
机译：越来越多的证据表明，胃食管反流病（GERD）是导致声音嘶哑，清嗓，嗓子不适，慢性咳嗽和呼吸急促的因素。 GERD与这些食管上症状之间的关联可能难以捉摸。超过50％的患者不存在胃灼热和反流。如果存在GERD征兆，症状无法解释或症状难以治疗，则应考虑反酸。尽管有仔细的病史和初步评估，GERD的诊断可能仍不清楚。诊断需要高度怀疑。当怀疑GERD时，宜进行抗反流治疗的经验性试验。目前，多探头动态pH监测是首选的诊断测试，但是对于GERD食管上表现的敏感性和特异性水平尚不确定。对抗反流疗法的反应比典型的GERD更难预测。通常需要更强的酸抑制作用和更长的治疗时间。

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