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首页> 外文期刊>Seizure: the journal of the British Epilepsy Association >Neuropsychological and behavioural aspects in children and adolescents with idiopathic epilepsy at diagnosis and after 12 months of treatment.
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Neuropsychological and behavioural aspects in children and adolescents with idiopathic epilepsy at diagnosis and after 12 months of treatment.

机译：诊断和治疗12个月后患有特发性癫痫的儿童和青少年的神经心理和行为方面。

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PURPOSE: To study neuropsychological functions in children with idiopathic epilepsy at onset of treatment and after 1 year of therapy and to identify factors associated with cognitive impairment. METHODS: 43 Subjects aged 5.2-16.9 years with newly diagnosed idiopathic epilepsy were enrolled and started treatment with valproate or carbamazepine. At admission and after 12 months, all patients underwent clinical examinations, the Child Behavioural Checklist, EEG and a neuropsychological test battery. The results of each test were correlated to demographic, clinical, electrophysiological and therapeutic variables. RESULTS: Except for attention, all neuropsychological functions were normal at admission and after 12 months. An improvement with time was noted for memory (p<0.05) and logical-executive functions (p<0.01). Attentive deficit was worse at 12 months (53.5% vs. 32.6%). Low socio-economic level and emotional and behavioural disturbances were the only factors negatively correlated to intelligence, memory and attention. Compared to valproate, carbamazepine was most commonly implicated. DISCUSSION: Idiopathic epilepsy can affect attention, even before starting treatment. Emotional and behavioural difficulties and a low socio-economical status are associated with cognitive impairment.
机译：目的：研究特发性癫痫儿童在治疗开始时和治疗1年后的神经心理功能，并确定与认知障碍相关的因素。方法：招募了43名年龄在5.2-16.9岁的新诊断为特发性癫痫的受试者，并开始用丙戊酸盐或卡马西平治疗。入院时和12个月后，所有患者均接受临床检查，儿童行为清单，脑电图和神经心理测验。每个测试的结果都与人口统计学，临床，电生理和治疗变量相关。结果：除注意力外，入院时和12个月后所有神经心理功能均正常。注意到记忆（p <0.05）和逻辑执行功能（p <0.01）随时间的改善。在12个月时，注意力不集中的情况更糟（53.5％对32.6％）。较低的社会经济水平以及情绪和行为障碍是与智力，记忆力和注意力负相关的唯一因素。与丙戊酸盐相比，卡马西平最常见。讨论：特发性癫痫甚至在开始治疗前就可能影响注意力。情绪和行为困难以及低社会经济地位与认知障碍有关。

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