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首页> 外文期刊>Seizure: the journal of the British Epilepsy Association >Clinical value of decreased superoxide dismutase 1 in patients with epilepsy
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Clinical value of decreased superoxide dismutase 1 in patients with epilepsy

机译：超氧化物歧化酶1减少在癫痫患者中的临床价值

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Purpose: Our previous study using proteomic analysis showed that superoxide dismutase 1 (SOD1) was significantly decreased in cerebrospinal fluid (CSF) of patients with epilepsy. However, the relevance of CSF-SOD1 alterations for the pathophysiology of epilepsy is currently unknown. The present study was intended to add to our understanding of this issue by measuring SOD1 levels in the CSF of patients with resistant epilepsy and non-resistant epilepsy. Methods: A total of 52 patients with epilepsy were recruited. 29 were non-resistant, 23 drug-resistant. 20 individuals with no evidence of any neurological diseases were used as control. The concentration of CSF and serum SOD1 was measured by enzyme-linked immunosorbent assay. Results: The concentration of CSF-SOD1 was decreased in both the drug-resistant (0.13 ± 0.12 ng/ml) and the non-resistant epilepsy subgroups (0.29 ± 0.23 ng/ml) compared to the control group (0.40 ± 0.35 ng/ml). SOD1 was significantly lower in the drug-resistant than the non-resistant epilepsy subgroup (P < 0.05). Conclusion: SOD1 levels are decreased in the CSF of patients with epilepsy, especially of patients with intractable epilepsy. Low CSF-SOD1 levels may be a predictor of antiepileptic drug resistance in patients with epilepsy.
机译：目的：我们先前使用蛋白质组学分析的研究表明，癫痫患者的脑脊液（CSF）中超氧化物歧化酶1（SOD1）明显降低。但是，目前尚不了解CSF-SOD1改变与癫痫的病理生理学的相关性。本研究旨在通过测量耐药性癫痫和非耐药性癫痫患者脑脊液中的SOD1水平来增加我们对该问题的认识。方法：共招募52例癫痫患者。非耐药29例，耐药23例。没有任何神经系统疾病证据的20个人被用作对照。用酶联免疫吸附法测定脑脊液和血清SOD1的浓度。结果：与对照组（0.40±0.35 ng / ml）相比，耐药（0.13±0.12 ng / ml）和非耐药性癫痫亚组（0.29±0.23 ng / ml）的CSF-SOD1浓度均降低。毫升）。耐药性亚组的SOD1明显低于耐药性亚组（P <0.05）。结论：癫痫患者，特别是顽固性癫痫患者的CSF中SOD1水平降低。 CSF-SOD1水平低可能是癫痫患者抗癫痫药耐药性的预测指标。

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