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首页> 外文期刊>Seminars in neonatology: SN >Placental inflammation.
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Placental inflammation.

机译：胎盘发炎。

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摘要

Placental inflammatory disorders represent a diverse and important category of pathological processes leading to fetal and neonatal morbidity and mortality. These processes can be divided into two broad subcategories, those caused by micro-organisms and those caused by host immune responses to non-replicating antigens. The mechanisms by which these inflammatory processes cause death and disability are diverse and can be separated into four distinct classes: placental damage with loss of function, induction of premature labour and subsequent preterm birth, release of inflammatory mediators leading to fetal organ damage and transplacental infection of the fetus. Each specific inflammatory process can be modulated by properties of the specific organism, the route and timing of infection and variations in the host's genetic background and immune responsiveness. All of these factors combine to produce specific patterns of placental pathology that can be used to guide treatment, predict complications and explain adverse outcome.
机译：胎盘炎性疾病代表导致胎儿和新生儿发病率和死亡率的多种多样且重要的病理过程。这些过程可分为两个大类，一个是微生物引起的，另一个是宿主对非复制性抗原的免疫反应引起的。这些炎症过程导致死亡和残疾的机制是多种多样的，可以分为四类：功能丧失的胎盘损害，引产和早产，早产，炎症介质释放导致胎儿器官损害和胎盘感染。胎儿每个特定的炎症过程都可以通过特定生物的特性，感染的途径和时机以及宿主遗传背景和免疫应答的变化来调节。所有这些因素共同产生了胎盘病理学的特定模式，可用于指导治疗，预测并发症和解释不良后果。

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