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首页> 外文期刊>Seizure: the journal of the British Epilepsy Association >Seizure control and biochemical profile on the ketogenic diet in young children with refractory epilepsy--Indian experience.
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Seizure control and biochemical profile on the ketogenic diet in young children with refractory epilepsy--Indian experience.

机译：难治性癫痫患儿生酮饮食的癫痫发作控制和生化特征-印度经验。

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AIM: This study evaluated the efficacy and tolerability of the ketogenic diet (KD) in young Indian children with refractory epilepsy. The changes in biochemical and lipid profile with KD were also assessed. METHODS: Children aged 6 months to 5 years who had daily seizures (or at least 7 seizures/week) despite the appropriate use of at least three antiepileptic drugs were enrolled. KD was introduced using a non-fasting gradual initiation protocol. Seizure frequency, biochemical profile (liver and kidney function tests, fasting lipid profile, and spot urinary calcium-creatinine ratio) and adverse effects were recorded. Patients continuing KD were followed up for a minimum period of 12 months. RESULTS: Twenty-seven children were enrolled. Non-fasting gradual KD initiation was well tolerated. Eighty-eight percent remained on KD at 3 months, 55% remained on KD at 6 months, and 37% remained on it at 1 year. Intention-to-treat analysis revealed that 48% (13 of 27) had >50% reduction in seizures, and four children (15 %) were seizure free at 6 months. At 1 year, 37% had >50% reduction in seizures and five children (18.5%) were seizure free. Adverse effects included constipation (74%), weight loss (14.8%), edema due to hypo-albuminemia (7.4%) and renal stones (3.7%). Biochemical profile did not reveal significant changes over time, except for reduced serum albumin and increased spot urinary calcium-creatinine ratio. CONCLUSION: KD is an effective and well-tolerated treatment option in young Indian children with refractory epilepsy. However, careful ongoing medical supervision is needed.
机译：目的：本研究评估了生酮饮食（KD）在印度难治性癫痫儿童中的疗效和耐受性。还评估了KD生化和脂质分布的变化。方法：招募了6个月至5岁的儿童，尽管适当使用了至少三种抗癫痫药，但他们仍每天发作（或每周至少发作7次）。 KD是使用非禁食的渐进启动方案引入的。记录癫痫发作频率，生化特征（肝和肾功能检查，空腹血脂特征和尿中尿钙肌酐比值）和不良反应。持续进行KD的患者至少随访12个月。结果：27名儿童入组。非空腹渐进性KD耐受性良好。 3个月时KD保留88％，6个月时KD保留55％，1年时保留37％。意向性治疗分析显示48％（27个中的13个）癫痫发作减少了50％以上，四个孩子（15％）在6个月内没有癫痫发作。在1岁时，癫痫发作的减少率> 50％，其中5％（18.5％）的儿童没有癫痫发作。不良反应包括便秘（74％），体重减轻（14.8％），低蛋白血症引起的水肿（7.4％）和肾结石（3.7％）。生化特征没有显示出随时间的显着变化，除了降低血清白蛋白和增加尿中尿钙肌酐的比率。结论：KD是印度顽固性癫痫儿童的一种有效且耐受良好的治疗选择。但是，需要仔细的持续医疗监督。

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