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首页> 外文期刊>Seizure: the journal of the British Epilepsy Association >Hemispheric asymmetry of callosal neuronal participation in bilaterally synchronous epileptiform discharges.
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Hemispheric asymmetry of callosal neuronal participation in bilaterally synchronous epileptiform discharges.

机译：双侧同步癫痫样放电中call神经元参与的半球不对称。

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PURPOSE: Callosal compound action potentials (CCAPs) recorded from the corpus callosum can reveal callosal neuronal activity. In this study, hemisphere-specific activity of callosal neurons during bilateral synchrony was evaluated in relation to the postoperative EEG. METHODS: In 19 patients undergoing callosotomy for intractable epilepsy, intraoperative electrocorticograms (ECoGs) and CCAPs were simultaneously recorded prior to callosal bisection. Hemisphere-specific CCAPs during bilateral synchrony were estimated through an averaging-based method. The degree of asymmetry in hemisphere-specific CCAPs was evaluated with a laterality index (LI), and correlated with post-callosotomy outcomes. RESULTS: Despite preoperative frequency of bilateral synchrony, postoperative EEG outcomes were mostly categorized as either unilaterally lateralized discharge group or bilaterally asynchronous discharge group. The LI of the former group was significantly higher than that of the latter group. In addition, higher amplitudes of the hemisphere-specific CCAP coincided with the side on which epileptiform discharges persisted postoperatively in most patients of the unilaterally lateralized discharge group. CONCLUSIONS: Electrophysiologic analysis with CCAPs revealed hemispheric asymmetry of callosal neuronal participation in bilateral synchrony. More callosal neurons fire together in the more epileptogenic hemisphere during bilateral synchrony even if preoperative EEG features are virtually symmetric. This suggests transcallosal dynamic actions on the bi-hemispheric epileptogenesis maintenance.
机译：目的：从call体记录的Call复合动作电位（CCAP）可以揭示call神经元的活动。在这项研究中，评估了双侧同步期间call神经元的半球特异性活动与术后脑电图的关系。方法：在19例因顽固性癫痫而进行切开术的患者中，同时记录了术中脑电图（ECoGs）和CCAP，然后再进行切开术。通过基于平均的方法估计双边同步期间的半球特异性CCAP。半球特异性CCAPs的不对称程度通过侧向指数（LI）进行评估，并与call切术后的结局相关。结果：尽管术前双侧同步化的频率较高，但术后脑电图的结果大多分为单侧偏侧出院组或双侧异步出院组。前一组的LI显着高于后一组。此外，在单侧偏侧出院组的大多数患者中，半球特异性CCAP的幅度更高，与癫痫样出院在术后持续的一侧相吻合。结论：CCAPs的电生理分析显示analysis神经元参与双边同步的半球不对称。即使术前脑电图特征实际上是对称的，在双侧同步过程中，更多的neuro神经元在更多的致癫痫性半球中共同发射。这表明跨callalalal动态作用在双半球癫痫发生维持。

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