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Analysis of steady state recycling chromatography using equilibrium theory

机译:平衡理论分析稳态循环色谱

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This paper presents a method for analysis and design of steady state recycling(SSR)chromatography under arbitrary purity or yield requirements.The approach applies to SSR processes in mixed-recycle operation and allows for the direct prediction of the steady state and the design parameters without performing dynamic simulations.Therefore,it simplifies optimal design of SSR processes and evaluation of process performance,while allowing minimizing the startup time of the process.It was shown that,when the purity and/or yield of the product fractions is specified,the total injection width is the only free operating parameter in mixed-recycle SSR chromatography.Theoretical analysis of the process revealed that the productivity is necessarily lower than that of an optimized separation by batch chromatography.On the other hand,the SSR process always outperforms batch chromatography in terms of eluent consumption and product concentrations.
机译:本文提出了一种在任意纯度或收率要求下进行稳态循环色谱分析和设计的方法,该方法适用于混合循环操作中的SSR工艺,可以直接预测稳态和设计参数而无需因此,它简化了SSR工艺的优化设计和工艺性能评估,同时使工艺的启动时间最小化。结果表明,指定产品馏分的纯度和/或收率时,总含量进样宽度是混合循环SSR色谱法中唯一的自由操作参数。对该方法的理论分析表明,其生产率必然低于分批色谱法优化的分离效率。洗脱液消耗量和产品浓度。

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