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Preparative chromatographic separation of amino acid racemic mixtures II.Modelling of the separation process

机译：氨基酸外消旋混合物的制备色谱分离II。分离过程模型

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摘要

Ligand exchange chromatography(LEC)using physically impregnated N-hexadecyl-L-hydroxyproline on commercially available RP-18 column is applied for the preparative separation of amino acid racemic mixtures.The equilibrium dispersive model was used for the mathematical prediction of the separation process.The experimental determination of the model parameters is discussed.Using the multi-component competitive Langmuir adsorption isotherm the mathematical model was able to predict the preparative separation behaviour of low concentrated feed solutions of amino acid racemats.The calculated profiles very well predict the break-through experiments(adsorption and desorption)as well as the injection experiments.At a high concentrated feed overloading effects in the break-through adsorption experiments were detected and a discussion on model limits is given.
机译：采用市售的RP-18色谱柱上物理浸渍的N-十六烷基-L-羟基脯氨酸进行的配体交换色谱法（LEC）用于氨基酸外消旋混合物的制备分离，并采用平衡分散模型对分离过程进行数学预测。讨论了模型参数的实验确定。利用多组分竞争朗缪尔吸附等温线，该数学模型能够预测氨基酸外消旋体低浓度进料溶液的制备分离行为。在高浓度进料中，在突破性吸附实验中发现了超载作用，并就模型极限进行了讨论。

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