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Effect of transmembrane pressure on rejection of viruses by ultrafiltration membranes

机译:跨膜压力对超滤膜对病毒排斥的影响

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摘要

Although partial penetration of ultrafiltration membranes by viruses and bacteria is well documented, there is no satisfactory explanation for the phenomenon. The current study seeks a possible explanation by studying the retention of viruses at different transmembrane pressures (TMPs). In contrast to previous predictions, higher TMPs lead to reduced virus retention levels. Based on indirect evidences it is proposed that the penetration occurs because of the formation during operation, rather than the initial presence, of abnormally large pores. It is therefore suggested that since pore enlargement is induced by high TMPs, high virus retention levels can be obtained only at low TMP values.
机译:尽管有充分的文献记载了病毒和细菌对超滤膜的部分渗透,但是对此现象还没有令人满意的解释。本研究通过研究病毒在不同跨膜压(TMP)下的保留力寻求可能的解释。与以前的预测相反,较高的TMP导致病毒保留水平降低。基于间接证据,提出渗透是由于在操作期间形成的,而不是最初存在的异常大的孔。因此建议由于高TMPs引起孔扩大,因此仅在低TMP值下才能获得高病毒保留水平。

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