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首页> 外文期刊>Separation and Purification Technology >Optimization of supercritical fluid extraction of dl-tetrahydropalmatine from rhizome of Corydalis yanhusuo W.T.Wang with orthogonal array design
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Optimization of supercritical fluid extraction of dl-tetrahydropalmatine from rhizome of Corydalis yanhusuo W.T.Wang with orthogonal array design

机译：正交试验法优化延胡索根茎中超临界流体萃取dl-四氢巴马汀的工艺

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摘要

df-Tetrahydropalmatine(dl-THP),an alkaloid occurring in plant,has been intensively studied due to its pharmacological actions.In this report,dl-THP from rhizome of Corydalis yanhusuo W.T.Wang was extracted using supercritical fluid extraction(SFE).Determinations of the extracts were performed by high-performance liquid chromatography.An orthogonal array design(OAD),OAg(3~4),was employed for optimization of supercritical fluid extraction of parameters of the compound.Four factors,namely various modifiers,the dynamic extraction time,temperature and pressure of the supercritical fluid,were studied and optimized by a three-level OAD.The effects of the parameters on the yield of d/-THP were studied using analysis of variance(ANOVA).Temperature had significant effect on the yield of dJ-THP,while the other three factors,i.e.various modifiers,dynamic extraction time and pressure,were not identified as significant factors under the selected conditions,based on ANOVA.The result shown that the optimization for the extraction condition of dl-THP was 1,2-propanediol used as modifier of supercritical CO2,extraction time 60 min,temperature 70 °C and pressure 200 bar,and that higher yield(1.324 mg/g)was obtained than that obtained by the other extraction condition.
机译：df-四氢巴马汀（dl-THP）是植物中存在的一种生物碱，由于其药理作用已得到深入研究。本报告中，使用超临界流体萃取（SFE）从延胡索延胡索的根茎中提取了dl-THP。萃取液采用高效液相色谱法进行分析。采用正交阵列设计（OAD）OAg（3〜4）优化化合物的超临界流体萃取参数。四因素，即各种改性剂，动力学通过三级OAD对超临界流体的萃取时间，温度和压力进行了研究和优化。使用方差分析（ANOVA）研究了参数对d / -THP产率的影响。温度对d / -THP的影响很大dJ-THP的收率，在选择的条件下，基于ANOVA，其他修饰剂，动态提取时间和压力这三个因素未被确定为重要因素。 dl-THP的萃取条件优化为1,2-丙二醇作为超临界CO2的改性剂，萃取时间60 min，温度70°C，压力200 bar，得到的收率高于（1.324 mg / g）。通过其他提取条件获得。

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