Up-titration of allopurinol in patients with gout

Jennings Claudine G.; Mackenzie Isla S.; Flynn Rob; Ford Ian; Nuki George; De Caterina Raffaele; Riches Philip L.; Ralston Stuart H.; MacDonald Thomas M.

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Up-titration of allopurinol in patients with gout

机译：痛风患者中别嘌醇的升高

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Objectives: European League against Rheumatism (EULAR) gout management guidelines recommend achieving a target urate level < 6.0 mg/dL (< 357 mu mol/L). Allopurinol is the most widely used urate-lowering therapy; however, many gout patients who are prescribed allopurinol do not have urate levels optimally controlled. The objective of this analysis was to review the efficacy and tolerability of allopurinol up-titration in achieving the EULAR target levels.

机译：目标：欧洲抗风湿病联盟（EULAR）痛风管理指南建议目标尿酸盐水平<6.0 mg / dL（<357 mu mol / L）。别嘌醇是最广泛使用的降低尿酸盐的疗法。但是，许多服用别嘌醇的痛风患者的尿酸水平没有得到最佳控制。该分析的目的是复查别嘌呤醇滴定在达到EULAR目标水平方面的功效和耐受性。

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来源
《Seminars in Arthritis and Rheumatism》 |2014年第1期|共6页
作者
Jennings Claudine G.; Mackenzie Isla S.; Flynn Rob; Ford Ian; Nuki George; De Caterina Raffaele; Riches Philip L.; Ralston Stuart H.; MacDonald Thomas M.;
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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
Gout; Allopurinol; Prescribing; Clinical guidelines;

机译：痛风;别嘌醇;处方;临床指南;

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1. Up-titration of allopurinol in patients with gout [J] . Jennings Claudine G., Mackenzie Isla S., Flynn Rob, Seminars in Arthritis and Rheumatism . 2014,第1期

机译：痛风患者中别嘌醇的升高
2. Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol [J] . Perez-Ruiz Fernando, Sundy John S., Miner Jeffrey N., Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2016,第6期

机译：Lesinurad联合别嘌呤醇：痛风患者对别嘌呤醇反应不足的2期，随机，双盲研究结果
3. Biochemical effectiveness of allopurinol and allopurinol-probenecid in previously benzbromarone-treated gout patients. [J] . Reinders MK, van-Roon EN, Houtman PM, Clinical rheumatology . 2007,第9期

机译：别嘌呤醇和别嘌呤醇-probenecid在先前苯溴马隆治疗的痛风患者中的生化有效性。
4. Characterization of auto-fluorescence urine crystals from gout patients using confocal microscopy and Micro-Raman system for urolithiasis prediction [C] . Zih-Ting Chen, Chih-Hao Wang, Huihua Kenny Chiang Conference on Biomedical Spectroscopy, Microscopy, and Imaging . 2020

机译：使用共聚焦显微镜和Micro-Raman系统表征痛风患者的自体荧光尿晶体，以预测尿路结石
5. Retrospective review of allopurinol dose and renal function in gout patients with and without allopurinol reactions. [D] . Silverberg, Miriam Shayna. 2010

机译：痛风患者有和没有别嘌呤醇反应的别嘌醇剂量和肾功能的回顾性回顾。
6. Extended report: Lesinurad in combination with allopurinol: results of a phase 2 randomised double-blind study in patients with gout with an inadequate response to allopurinol [O] . Fernando Perez-Ruiz, John S Sundy, Jeffrey N Miner, -1

机译：扩展报告：Lesinurad联合别嘌呤醇：痛风患者对别嘌呤醇反应不足的2期随机双盲研究结果
7. Biochemical effectiveness of allopurinol and allopurinol-probenecid in previously benzbromarone-treated gout patients [O] . Reinders M.K., van Roon E.N., Houtman P.M., 2007

机译：别嘌呤醇和别嘌呤醇-前苯丙酮酸在先前苯溴马隆治疗的痛风患者中的生化有效性

Up-titration of allopurinol in patients with gout

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