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首页> 外文期刊>Seminars in Arthritis and Rheumatism >Effects of tofacitinib and other DMARDs on lipid profiles in rheumatoid arthritis: implications for the rheumatologist
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Effects of tofacitinib and other DMARDs on lipid profiles in rheumatoid arthritis: implications for the rheumatologist

机译：托法替尼和其他DMARD对类风湿关节炎脂质谱的影响：对风湿病学家的影响

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摘要

Cardiovascular (CV) morbidity and mortality are increased in patients with active, untreated rheumatoid arthritis (RA), despite lower levels of total and low-density lipoprotein cholesterol reported in individuals with active RA compared with those without RA. Alterations in non-traditional lipid assessments, such as high-density lipoprotein (HDL) function and HDL-associated proteins, have been described in patients with active RA, including elevated HDL-associated serum amyloid A and decreased paraoxonase-1 activity. We review changes in both traditional lipoprotein concentrations and non-traditional lipoprotein assessments in multiple studies of treatment with disease-modifying antirheumatic drugs (DMARDs), including non-biologic and biologic DMARDs and tofacitinib. In addition, data from a recently published clinical trial with tofacitinib that describe a potential mechanism for suppression of cholesterol levels in active RA patients are reviewed. Finally, CV event data from various studies of DMARDs are presented, and the current management of RA patients with regard to the CV risk is reviewed. (C) 2016 The Authors. Published by Elsevier HS Journals, Inc.
机译：活动性，未经治疗的类风湿性关节炎（RA）患者的心血管（CV）发病率和死亡率增加，尽管活动性RA患者的总和低密度脂蛋白胆固醇水平低于无RA患者。非传统脂质评估的变化，例如高密度脂蛋白（HDL）功能和与HDL相关的蛋白，已被描述为患有活动性RA的患者，包括与HDL相关的血清淀粉样蛋白A升高和对氧磷酶-1活性降低。我们在多种疾病修饰抗风湿药（DMARDs）（包括非生物和生物DMARDs和托法替尼）的治疗研究中回顾了传统脂蛋白浓度和非传统脂蛋白评估的变化。另外，综述了来自最近发表的托法替尼临床试验的数据，该数据描述了抑制活跃RA患者胆固醇水平的潜在机制。最后，介绍了来自各种DMARD研究的CV事件数据，并对RA患者在CV风险方面的当前管理进行了回顾。 （C）2016作者。由Elsevier HS Journals，Inc.发布

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