Mitochondrial dynamics and cancer.

Grandemange S; Herzig S; Martinou JC

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Mitochondrial dynamics and cancer.

机译：线粒体动力学和癌症。

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Mitochondrial morphology is regulated by continuous fusion and fission events that are essential for maintaining a normal mitochondrial function. If the last years have witnessed major discoveries in the characterization of the fission and fusion machineries, little is known about the physiological role of mitochondrial dynamics. In this review we report the results showing evidences of relationships between mitochondrial dynamics and cellular metabolism, autophagy or apoptosis. We discuss how different mitochondrial alterations observed in cancer cells could be linked to unbalanced mitochondrial fission or fusion events and how this could impinge on key essential cellular processes, thereby contributing to tumorigenesis.

机译：线粒体形态受连续融合和裂变事件的调节，这对于维持正常的线粒体功能至关重要。如果最近几年在裂变和融合机制的表征方面取得了重大发现，那么线粒体动力学的生理作用还鲜为人知。在这篇综述中，我们报告的结果显示了线粒体动力学与细胞代谢，自噬或细胞凋亡之间关系的证据。我们讨论了如何在癌细胞中观察到的不同线粒体变化与不平衡的线粒体裂变或融合事件有关，以及这如何影响关键的基本细胞过程，从而促进肿瘤发生。

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《Seminars in cancer biology》 |2009年第1期|共7页
作者
Grandemange S; Herzig S; Martinou JC;
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正文语种 eng
中图分类肿瘤学;
关键词
Animals; Apoptosis; Autophagy; Cell Cycle; Energy Metabolism; Humans; Mitochondria; 动物; 脱噬作用; 细胞周期; 能量代谢; 线粒体; 肿瘤; 原致癌基因蛋白质 c-bcl-2;

机译：Animals;Apoptosis;Autophagy;Cell Cycle;Energy Metabolism;Humans;Mitochondria;动物;脱噬作用;细胞周期;能量代谢;线粒体;肿瘤;原致癌基因蛋白质 c-bcl-2;

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1. Mitochondrial dynamics and cancer. [J] . Grandemange S, Herzig S, Martinou JC Seminars in cancer biology . 2009,第1期

机译：线粒体动力学和癌症。
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3. Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways [J] . Yasmin Simchoni, Anna Melkov, Yehonatan Alcalay, Biology Open . 2015,第12期

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4. Mitochondrial Permeability Transition Dynamics: An Indicator of Mitochondrial Potassium Channel Opener [C] . Fang Shen, Li-ping Wu, Yuan Lu, . 2005

机译：线粒体通透性转变动力学：线粒体钾通道开放剂的指标。
5. Role of Mitochondrial Dynamics and Autophagy in Removal of Helix-Distorting Mitochondrial DNA Damage. [D] . Bess, Amanda Smith. 2012

机译：线粒体动力学和自噬在消除扭曲螺旋线粒体DNA损伤中的作用。
6. Nanoscopic quantification of sub-mitochondrial morphology mitophagy and mitochondrial dynamics in living cells derived from patients with mitochondrial diseases [O] . Weiwei Zou, Qixin Chen, Jesse Slone, 2021

机译：源自线粒体疾病患者的活细胞中亚线粒体形态水肿和线粒体动力学的纳米镜测量
7. Faculty Opinions recommendation of Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancer. [O] . Jean-Pierre Gillet 2020

机译：教师观念推荐线粒体移植调节乳腺癌中的抗肿瘤活性，化学抑制和线粒体动力学。

Mitochondrial dynamics and cancer.

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