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Manipulation of the tumor suppressor p53 for potentiating cancer therapy.

机译:操纵抑癌剂p53增强癌症治疗。

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摘要

The tumor suppressor p53 is a linchpin in the regulation of appropriate cellular responses to various stress conditions. Inactivation of the functions of this critical participant can have diabolical consequences, in particular the development of malignant diseases. Elicitation of appropriate p53 functions is an attractive strategy for combating cancer. Triggering p53 responses, reconstituting p53 activities through gene therapy, coercing mutant p53 to perform normal functions, manipulating p53 regulators, and activating p53 effectors are all approaches that are currently being developed. Here, we will overview 'p53-based' strategies for fighting cancer, both those under clinical trial and recent innovative concepts.
机译:肿瘤抑制因子p53在调节对各种应激条件的适当细胞应答中起关键作用。该关键参与者功能的失活可能产生恶性后果,特别是恶性疾病的发展。激发适当的p53功能是对抗癌症的一种有吸引力的策略。触发p53反应,通过基因疗法重建p53活性,强迫突变p53执行正常功能,操纵p53调节剂以及激活p53效应子都是目前正在开发的方法。在这里,我们将概述处于临床试验和最新创新观念下的“基于p53的”抗癌策略。

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