• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Sexually Transmitted Infections >Oral shedding of herpes simplex virus type 2.
【24h】

Oral shedding of herpes simplex virus type 2.

机译：口腔单纯疱疹病毒2型脱落。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: Herpes simplex virus (HSV) 1 and HSV-2 reactivate preferentially in the oral and genital area, respectively. We aimed to define frequency and characteristics associated with oral shedding of HSV-2. METHODS: Demographic, clinical and laboratory data of patients with documented HSV-2 infection and at least one oral viral culture obtained were selected from the University of Washington Virology Research Clinic database. RESULTS: Of 1388 people meeting the entry criteria, 44 (3.2%) had HSV-2 isolated at least once from their mouths. In comparison with the 1344 people who did not have HSV-2 isolated from their mouth, participants with oral HSV-2 were more likely to be male (OR = 1.9, 95% CI 1.0 to 3.7), HIV positive (OR = 2.9, 95% CI 1.4 to 6.0), and homosexual (OR = 2.2, 95% CI 1.1 to 4.2), and to have collected a larger number of oral specimens (median 32 v 4, p<0.001). Of the 58 days with oral HSV-2 isolation, 15 (25%) occurred during newly acquired HSV-2 infection, 12 (21%) during a recurrence with genital lesions, three (5%) during a recurrence with oral lesions, and three (5%) during a recurrence with oral and genital lesions; 25 (43%) occurred during asymptomatic shedding. Oral HSV-2 was found less frequently than oral HSV-1 (0.06% v 1%, p<0.001) in people with HSV-1 and HSV-2 antibody, and less frequently than genital HSV-2 (0.09% v 7%, p<0.001). CONCLUSIONS: Oral reactivation of HSV-2 as defined by viral isolation is uncommon and usually occurs in the setting of first episode of genital HSV-2 or during genital recurrence of HSV-2.
机译：目的：单纯疱疹病毒（HSV）1和HSV-2分别在口腔和生殖器区域优先激活。我们旨在定义与HSV-2口腔脱落相关的频率和特征。方法：从华盛顿大学病毒学研究数据库中选择已记录HSV-2感染并至少获得一种口腔病毒培养的患者的人口统计学，临床和实验室数据。结果：在符合入组标准的1388人中，有44名（3.2％）的HSV-2从口腔中分离出至少一次。与没有从口腔中分离出HSV-2的1344人相比，口服HSV-2的参与者更可能是男性（OR = 1.9，95％CI 1.0至3.7），HIV阳性（OR = 2.9， 95％CI 1.4到6.0）和同性恋（OR = 2.2，95％CI 1.1到4.2），并且已经收集了更多的口腔标本（中位数32 v 4，p <0.001）。在经口HSV-2隔离的58天中，有15例（25％）在新获得的HSV-2感染期间发生，在生殖器病变复发期间12例（21％），在口腔病变复发期间3例（5％），以及口腔和生殖器病变复发期间占三（5％）; 25例（43％）在无症状脱落期间发生。在具有HSV-1和HSV-2抗体的人群中，口服HSV-2的频率低于口服HSV-1（0.06％v 1％，p <0.001），并且频率低于生殖器HSV-2（0.09％v 7％） ，p ＜0.001）。结论：病毒分离所定义的HSV-2口服再激活并不常见，通常发生在生殖器HSV-2首次发作的环境中或生殖器HSV-2复发期间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号