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Relationship of Estimated SHIV Acquisition Time Points During the Menstrual Cycle and Thinning of Vaginal Epithelial Layers in Pigtail Macaques

机译:短尾猕猴月经周期中阴道感染的估计HIV感染时间点与阴道上皮层变薄的关系

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摘要

Background HIV acquisition in the female genital tract remains incompletely understood. Quantitative data on biological HIV risk factors, the influence of reproductive hormones, and infection risk are lacking. We evaluated vaginal epithelial thickness during the menstrual cycle in pigtail macaques (Macaca nemestrina). This model previously revealed increased susceptibility to vaginal infection during and after progesterone-dominated periods in the menstrual cycle.
机译:在女性生殖道中感染HIV的背景仍然不完全清楚。缺乏有关艾滋病毒生物危险因素,生殖激素的影响和感染风险的定量数据。我们评估了尾巴猕猴(Macaca nemestrina)在月经周期的阴道上皮厚度。该模型先前显示在月经周期中以孕酮为主的时期和之后,对阴道感染的敏感性增加。

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