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首页> 外文期刊>Biomaterials >Slow release of the antimetabolite 5-fluorouracil (5-FU) from modified Baerveldt glaucoma drains to prolong drain function.
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Slow release of the antimetabolite 5-fluorouracil (5-FU) from modified Baerveldt glaucoma drains to prolong drain function.

机译：从改良的Baerveldt青光眼引流剂缓慢释放抗代谢物5-氟尿嘧啶（5-FU），以延长引流功能。

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摘要

Drainage devices are routinely placed in the eyes of patients with glaucoma to reduce intraocular pressure (IOP) by providing controlled outflow of fluid (aqueous humor) via a filtering bleb. However, the natural wound healing response often interferes with fluid outflow by thickening the walls of the bleb over time, so that these devices rarely remain functional for more than 5 years. We investigated the use of controlled release of an antimetabolite, 5-fluorouracil (5-FU), within glaucoma drains to determine if the wound healing response could be reduced and the useful life span of the device increased. Collagen plugs containing 1.125 mg of 5-FU were placed in the silicone tubes of modified Baerveldt glaucoma drains. Eight drains with 5-FU and eight drains without 5-FU were implanted in one eye each of 16 New Zealand white rabbits: the contralateral eyes served as unoperated controls. Results were evaluated in terms of IOP, fibrous capsule thickness, macrophage density. and presence of type III collagen surrounding the drain plate, 3 and 6 months after implantation. In general, eyes implanted with antimetabolite-containing drains demonstrated significantly lower values for all evaluated parameters at 3 months and lower or equal values at 6 months, compared with the eyes not receiving 5-FU and the unoperated controls, indicating improved IOP-lowering function, reduced bleb wall thickness, and earlier achievement of a steady-state wound healing response. All eyes remained healthy throughout the 6-month duration of the study with no cytotoxicity complications in any of the eyes. Thus, biodegradable plugs placed within the silicone tubes of glaucoma drains can safely deliver 5-FU to filtering blebs over time, which could prolong the functional life of the bleb by decreasing the thickness of the anterior fibrous capsule and permitting sufficient fluid outflow to reduce IOP to physiological levels.
机译：通常在青光眼患者的眼中放置引流装置，以通过过滤泡提供受控的液体流出（房水）来降低眼内压（IOP）。但是，自然的伤口愈合反应通常会随着时间的流逝而使气泡壁变厚，从而干扰液体流出，因此这些设备很少能保持功能超过5年。我们研究了在青光眼引流管中使用抗代谢药物5-氟尿嘧啶（5-FU）的控制释放，以确定是否可以减少伤口的愈合反应并延长器械的使用寿命。将含有1.125 mg 5-FU的胶原蛋白栓塞放入改良的Baerveldt青光眼引流管的硅胶管中。在16只新西兰白兔的每只眼中分别植入8个带5-FU的引流管和8个不带5-FU的引流管：将对侧眼作为未手术的对照。根据IOP，纤维囊厚度，巨噬细胞密度评估结果。植入后3个月和6个月时，引流板周围是否存在III型胶原蛋白。通常，与未接受5-FU和未手术的对照相比，植入含抗代谢物的引流眼在3个月时所有评估参数的值均显着降低，而在6个月时均降低或相等值，表明IOP降低功能得到改善，减少了气泡壁的厚度，并更早地实现了稳态伤口愈合反应。在整个研究的6个月中，所有眼睛都保持健康，任何眼睛都没有细胞毒性并发症。因此，放置在青光眼引流管内的可生物降解的栓塞可以随着时间的流逝安全地将5-FU输送至滤泡，这可以通过减小前纤维囊的厚度并允许足够的液体流出以减少IOP来延长滤泡的使用寿命。达到生理水平。

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