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How to make a static cy to kinetic furrow out of traveling excitable waves

机译：如何通过行进的可激发波使静态cy变为动态犁沟

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Emergence of the cytokinetic Rho zone that orchestrates formation and ingression of the cleavage furrow had been explained previously via microtubule-dependent cortical concentration of Ect2, a guanine nucleotide exchange factor for Rho. The results of arecent publication now demonstrate that, en route from resting cortex to fully established furrow, there lies a regime of cortical excitability in which Rho activity and F-actin play the roles of the prototypical activator and inhibitor, respectively. This cortical excitability is manifest as dramatic traveling waves on the cortex of oocytes and embryos of frogs and starfish. These waves are initiated by autocatalytic activation of Rho at the wave front and extinguished by F-actin-dependent inhibitionat their back. It is still unclear how propagating excitable Rho-actin waves give rise to the stable co-existence of Rho activity and F-actin density in the static cleavage furrow during cytokinesis. It is possible that some central spindle-associated signaling molecule simply turns off the inhibition of Rho activity by F-actin. However, mathematical modeling suggests a distinct scenario in which local "re-wiring" of the Rho-actin coupling in the furrow is no longer necessary. Instead, the model predicts that the continuously rising level of Ect2 produces in the furrow a qualitatively new stable steady state that replaces excitability and brings about the stable co-existence of high Rho activity and dense F-actin despite the continuing inhibition of Rho by F-actin.
机译：以前已经通过微管依赖的皮质浓度Ect2（Rho的鸟嘌呤核苷酸交换因子）解释了协调分裂沟的形成和进入的细胞动力学Rho区的出现。现在最新发表的结果表明，在从静止的皮质到完全建立的犁沟的途中，存在着一种皮质兴奋性机制，其中Rho活性和F-肌动蛋白分别起原型激活剂和抑制剂的作用。这种皮层兴奋性表现为卵母细胞皮层以及青蛙和海星胚胎上的剧烈行进波。这些波是由波前的Rho自身催化活化引发的，而在其后部由F-肌动蛋白依赖性抑制而熄灭。尚不清楚如何传播的可激发的Rho-肌动蛋白波在细胞分裂过程中如何引起Rho活性和F-肌动蛋白密度在静态卵裂沟中的稳定并存。一些与中心纺锤体相关的信号分子可能会简单地终止F-肌动蛋白对Rho活性的抑制。但是，数学建模提出了一种独特的方案，在该方案中，不再需要在犁沟中局部“重新布线” Rho-肌动蛋白偶合。取而代之的是，该模型预测，Ect2的持续升高会在犁沟中产生定性的新稳定态，从而取代兴奋性，并且尽管F持续抑制Rho，但仍会导致高Rho活性和致密F-肌动蛋白的稳定共存。 -肌动蛋白。

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