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首页> 外文期刊>Small Ruminant Research >Relationship between genetic variants of POUIF1, PROP1, IGFBP3 genes and milk performance in Guanzhong dairy goats
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Relationship between genetic variants of POUIF1, PROP1, IGFBP3 genes and milk performance in Guanzhong dairy goats

机译：关中奶山羊POUIF1，PROP1，IGFBP3基因遗传变异与产奶性能的关系

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The aim of this study was to determine and verify if the potential genetic variations in the POU1F1, PROP1 and IGFBP3 genes could be related to dairy goat milk performance. This study detected the polymorphisms of POU1FI-PstI,POUlF1-Ddel,POU1F1-Alul, PROP1-Hin61 and IGFBP3-Xspl loci, and evaluated their associations with milk performance in Guanzhong dairy goats. The present results confirmed the previous genotypes and found three unreported genotypes in Guanzhong dairy goats (e.g. genotype D2D2 at POUIF1-DdeI locus, genotype TC at POU1F1-Alul locus, genotype X2X2 at IGFBP3-XspI locus, respectively). The genotypic frequencies of all analyzed loci were at Hardy -Weinberg equilibrium (P> 0.05) except POU1F1-Pstl locus (P 0.01). The PIC values of POU1F1-Pstl locus and IGFBP3-Xspl locus were 0.328 and 0.329, respectively, suggesting that these two loci possessed median polymorphism. Association analysis demonstrated no significant relationship between the POU1F1-Pstl, POU1F1-Ddel, PROP1-Hin61 and IGFBP3-Xspl loci and milk performance in Guanzhong dairy goats (P> 0.05). Interestingly, in the POU1F1Alul locus, this SNP was significantly associated with a total of six milk traits (P 0.05). Moreover, the individuals with genotype TT possessed superior morning milk fat content, afternoon milk fat content and average milk fat when compared with those of genotype TC (P= 0.026, P=0.029, P= 0.036, respectively); Consistently, genotype TT had higher morning milk acidity, afternoon milk acidity and average milk acidity than genotype TC (P= 0.028, P = 0.027, P = 0.038, respectively). These findings suggested that the POUlF1-Alul locus had significantly effect on milk performance, and genotype TT could become an effective DNA marker for senior milk fat content or acidity, which could benefit to dairy goat selection and breeding through marker -assisted selection (MAS). (C) 2016 Elsevier B.V. All rights reserved.
机译：这项研究的目的是确定和验证POU1F1，PROP1和IGFBP3基因的潜在遗传变异是否与奶山羊的乳汁性能有关。本研究检测了POU1FI-PstI，POUlF1-Ddel，POU1F1-Alul，PROP1-Hin61和IGFBP3-Xspl基因座的多态性，并评估了它们与关中奶山羊产奶性能的关系。目前的结果证实了先前的基因型，并在关中奶山羊中发现了三种未报告的基因型（例如，POUIF1-DdeI位点的基因型为D2D2，POU1F1-Aul1位点的基因型为TC，IGFBP3-XspI位点的基因型为X2X2）。除POU1F1-Pstl基因座（P <0.01）外，所有分析基因座的基因型频率均处于Hardy-Weinberg平衡（P> 0.05）。 POU1F1-Pstl基因座和IGFBP3-Xspl基因座的PIC值分别为0.328和0.329，表明这两个基因座具有中位多态性。关联分析表明，关中奶山羊的POU1F1-Pstl，POU1F1-Ddel，PROP1-Hin61和IGFBP3-Xspl位点与产奶量之间无显着相关性（P> 0.05）。有趣的是，在POU1F1Alu1基因座中，该SNP与总共六个乳性状显着相关（P <0.05）。此外，与基因型TC相比，基因型TT的个体具有较高的早晨乳脂含量，下午乳脂含量和平均乳脂（分别为P = 0.026，P = 0.029，P = 0.036）;一致地，基因型TT比基因型TC具有更高的早晨乳汁酸度，下午乳汁酸度和平均乳汁酸度（分别为P = 0.028，P = 0.027，P = 0.038）。这些发现表明，POUlF1-Alul基因座对牛奶性能有显着影响，基因型TT可能成为高级牛奶脂肪含量或酸度的有效DNA标记，这可以通过标记辅助选择（MAS）有利于奶山羊的选择和育种。 。 （C）2016 Elsevier B.V.保留所有权利。

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