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首页> 外文期刊>Skeletal radiology >T1-weighted MR imaging for distinguishing large osteolysis of Paget's disease from sarcomatous degeneration.
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T1-weighted MR imaging for distinguishing large osteolysis of Paget's disease from sarcomatous degeneration.

机译：T1加权MR成像可区分Paget病的大骨溶解与肉瘤样变性。

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OBJECTIVE: To report five symptomatic patients, four with unequivocal Paget's disease and large areas of osteolysis and one patient with presumed osteolytic Paget's disease, evaluated by MR imaging to confirm or exclude a sarcoma. DESIGN AND PATIENTS: Four men and one woman (median age 74 years) presented with new symptoms of pain. Four of these patients had unequivocal Paget's disease with large areas of osteolysis; one patient presented with large focal osteolysis and no other finding. MR imaging was performed in each case to exclude malignancy in the area of osteolysis. RESULTS: Two patients whose MR images showed a low signal abnormality on the T1-weighted sequence corresponding to osteolysis on the radiograph were found to have malignant degeneration. Three patients with osteolytic lesions on T1-weighted MR imaging showed preservation of fat signal in the areas of osteolysis, were not biopsied and have been free of malignant disease for from 12 months to 2 1/2 years. One patient had one area of osteolysis in the iliac bone which showed malignancy and another area of osteolysis which showed preservation of fat signal on the T1-weighted sequence. CONCLUSIONS: The information obtained from T1-weighted MR imaging sequences performed on patients with Paget's disease who have new symptoms and large areas of osteolysis could reliably be used in the clinical decision-making process between conservative follow-up and biopsy.
机译：目的：报告5例有症状的患者，其中4例患有明确的Paget病并发生大范围的骨溶解，另一例患有假定的溶骨性Paget病，并通过MR成像评估以确认或排除肉瘤。设计和患者：4名男性和1名女性（中位年龄74岁）表现出新的疼痛症状。这些患者中有四个患有明确的Paget病，并有大范围的骨溶解。一名患者出现大的局灶性骨溶解，无其他发现。在每种情况下均进行MR成像以排除骨溶解区域的恶性肿瘤。结果：两名患者的MR图像在T1加权序列上显示出低信号异常，这与X线片上的骨溶解相对应，被发现患有恶性变性。 T1加权MR成像的三例溶骨性病变患者在溶骨区域显示脂肪信号得以保留，未进行活检，并且在12个月至2 1/2年内无恶性疾病。一名患者在the骨中有一个骨溶解区域显示出恶性，而在T1加权序列中另一个骨溶解显示了脂肪信号的保留。结论：从T1加权MR成像序列中获得的信息，对具有新症状和大范围骨溶解的佩吉特病患者进行的T1加权MR成像信息可可靠地用于保守随访和活检之间的临床决策过程中。

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