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首页> 外文期刊>Skeletal radiology >De novo malignant transformation of giant cell tumor of bone.
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De novo malignant transformation of giant cell tumor of bone.

机译：从头开始恶性转化骨巨细胞瘤。

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Two cases of malignant lesions are reported, both of which arose secondary to an originally benign giant cell tumor (GCT) of bone. The first case was a typical benign GCT, which occurred in the left proximal tibia of a 31-year-old woman. The tumor was treated by curettage and bone grafting. However, it recurred twice during 15 years of follow-up. The second recurrence showed that the lesion histologically had turned into malignant fibrous histiocytoma. The second case also started as an initially benign GCT that arose in the left distal femur of a 41-year-old man. The patient underwent curettage and bone grafting. The lesion recurred 13 years postoperatively. The histological appearance of the recurrent tumor showed it to be an osteogenic sarcoma. In both patients, radiation and never been given. Malignant transformation has rarely been reported in patients with GCT of bone who have not received radiation treatment.
机译：据报道有两例恶性病变，均起源于原本良性的骨巨细胞瘤（GCT）。第一例是典型的良性GCT，发生在一名31岁妇女的左胫骨近端。通过刮除术和植骨治疗肿瘤。但是，在15年的随访中，它两次复发。第二次复发显示，病变在组织学上已转变为恶性纤维组织细胞瘤。第二例也始于最初良性的GCT，发生在一名41岁男性的左股骨远端。患者进行刮除术和植骨。术后13年复发。复发性肿瘤的组织学表现表明它是成骨肉瘤。在这两名患者中，从未接受放射治疗。尚未接受放射治疗的骨GCT患者很少报告恶变。

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