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首页> 外文期刊>Skin research and technology: official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) >Buffering capacity of human skin layers: in vitro.
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Buffering capacity of human skin layers: in vitro.

机译：人体皮肤层的缓冲能力：体外。

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BACKGROUND/PURPOSE: The skin possesses buffering capacity to resist acidic/alkaline aggression. Skin components contribute differently to this buffering capacity. This study investigates buffering capacity in three skin layers: intact stratum corneum (SC), epidermis and dermis. METHODS: Sodium hydroxide (NaOH) and hydrochloric acid (HCl) solutions at 0.025, 0.05 and 0.1 N were applied to skin (3.18 muL/cm(2)). After 30 min, the skin was washed with 1 mL de-ionized water. TEWL and pH measurements were conducted at baseline (before contact with acid or base), 0, 10 and 30 min post exposure, and continued at 0, 10 and 30 min post washing. RESULTS: Data indicate that immediately following acid or base exposures, the dermis demonstrates the highest buffering capacity, while with time, intact stratum corneum predominates. CONCLUSION: These findings potentiate advanced understanding of skin's buffering capacity as related to dermatopharmacology and dermatotoxicology.
机译：背景/目的：皮肤具有抵抗酸性/碱性侵袭的缓冲能力。皮肤成分对此缓冲能力的贡献不同。这项研究调查了三个皮肤层的缓冲能力：完整的角质层（SC），表皮和真皮。方法：将0.025、0.05和0.1 N的氢氧化钠（NaOH）和盐酸（HCl）溶液施用于皮肤（3.18μL/ cm（2））。 30分钟后，用1 mL去离子水清洗皮肤。在基线（与酸或碱接触之前），暴露后0、10和30分钟进行TEWL和pH测量，并在洗涤后0、10和30分钟继续进行。结果：数据表明，暴露于酸或碱之后，真皮具有最高的缓冲能力，而随着时间的推移，完整的角质层占主导地位。结论：这些发现增强了对与皮肤药理学和皮肤毒理学有关的皮肤缓冲能力的高级理解。

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