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首页> 外文期刊>Signal transduction: Receptors, mediators and genes: Official journal of the Signal Transduction Society >The sea urchin and cellular and developmental signaling mechanisms
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The sea urchin and cellular and developmental signaling mechanisms

机译：海胆与细胞和发育的信号传导机制

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摘要

On a beach near Monterey, California in the summer of 1986, I read and article concerning a recommendation by an august committee concerning which organisms should serve as future model organisms for molecular and cellular biological research (and conincidentally, for funding). I was disappointed to learn that my favorite organism, the sea urchin, was not included in the list. A major argument, I recall, was that given limited resources and the diversity of living organisms, we needed to focus on those most amenable to investigation (mainly because of their tractable genetics). The model list was similar to that which can be currently found on the NIH website http://www.nih. gov/science/models which includes the familiar mouse, rat, budding and fission yeast, Dictvostelium, G. elegans, Drosophila, Arabidopsis, the zebrafish and the frog. It was largely from a reductionist viewpoint that it was argued that molecular and cellular aspects of these organisms would tell us much of what we could need to know about the millions of other extant organisms.
机译：1986年夏天，在加利福尼亚州蒙特雷附近的海滩上，我读到一篇文章，内容涉及一个庄严的委员会的建议，该建议涉及哪些生物应作为分子和细胞生物学研究的未来模式生物（并偶然获得资助）。令我失望的是，我最喜欢的生物海胆未列入清单。我记得一个主要论点是，由于资源有限和生物多样性，我们需要集中精力研究最适合调查的生物（主要是因为它们的遗传学易处理）。该型号清单与NIH网站http：//www.nih上当前可找到的型号清单相似。 gov / science / models，包括熟悉的小鼠，大鼠，发芽和裂变酵母，Dictvostelium，线虫G，线虫，拟南芥，斑马鱼和青蛙。人们主要是从还原论的观点出发，认为这些生物的分子和细胞方面将告诉我们许多我们需要了解的数百万其他现存生物的信息。

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