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首页> 外文期刊>Signal transduction: Receptors, mediators and genes: Official journal of the Signal Transduction Society >Mutual antagonism of SoxB1 and canonical Wnt signaling in sea urchin embryos
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Mutual antagonism of SoxB1 and canonical Wnt signaling in sea urchin embryos

机译：海胆胚胎中SoxB1与经典Wnt信号的相互拮抗作用

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摘要

Early development of animal embryos involves establishing axial polarities that specify the anlage of major tissues in a 3-dimensional pattern. Cell fates are specified on this coordinate system through a combination of differential inheritance of maternal regulatory molecules and signaling interactions among cells. Correct patterning of cell fates along the primary axis of the sea urchin embryo depends on tightly regulating the ratio of activities of two nuclear regulatory proteins, SoxB1 and nuclear β-catenin. The latter acts at the top of the gene regulatory network that specifies mesoderm and endoderm and activates, directly or indirectly, signaling by Delta, Wnt8 and Nodal. In contrast, SoxB1 initially accumulates in all nuclei but is progressively eliminated from presumptive mesoderm and endoderm by β-catenin-dependent transcriptional repression and by localized protein turnover, a novel pathway acting downstream of canonical Wnt signaling. A precise temporal program for SoxB1 down regulation is crucial for endomesoderm development because SoxB1 interferes with β-catenin's transcriptional regulatory function. The mechanisms we are beginning to understand that govern the β-catenin-SoxB1 antagonism in sea urchin embryos are likely to have broad significance, since Sox factors are involved in regulating many developmental processes in many deuterostome embryos.
机译：动物胚胎的早期发育涉及建立轴向极性，该轴向极性以3维模式指定主要组织的损伤。通过将母体调节分子的差异遗传和细胞之间的信号相互作用相结合，可以在此坐标系上指定细胞命运。沿着海胆胚胎主轴排列的细胞命运的正确模式取决于紧密调节两种核调节蛋白SoxB1和核β-连环蛋白的活性比。后者在指定中胚层和内胚层的基因调节网络的顶部起作用，并直接或间接激活Delta，Wnt8和Nodal的信号传导。相反，SoxB1最初在所有细胞核中积累，但通过β-连环蛋白依赖性转录抑制和局部蛋白更新（一种在经典Wnt信号下游起作用的新途径）逐渐从推测的中胚层和内胚层中消除。 SoxB1下调的精确时间程序对于内胚层发育至关重要，因为SoxB1会干扰β-catenin的转录调节功能。我们开始认识到控制海胆胚胎中β-catenin-SoxB1拮抗作用的机制可能具有广泛的意义，因为Sox因子参与了许多氘核胚胎中许多发育过程的调控。

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