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首页> 外文期刊>Signal transduction: Receptors, mediators and genes: Official journal of the Signal Transduction Society >TGF-β receptors: Assembly, signalling, and disease relevance
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TGF-β receptors: Assembly, signalling, and disease relevance

机译：TGF-β受体：组装，信号传导和疾病的相关性

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摘要

TGF-β superfamily members exert their biological effects by binding to type I, type II and type III cell surface receptors. While the type I and type II receptors entail serine/threonine kinase domains and form signalling entities upon ligand binding, the type III receptors represent accessory receptors with no discernible kinase function identified to date. In TGF-β signalling, a heterotetrameric complex of the type I and II receptors is induced upon ligand binding, which promotes signal transduction through intracellular Smad proteins. Recent studies have indicated that type I and type II oligomerisation dynamics, which mainly serve to promote signalling purposes of TGF-β ligands, can also exert functional antagonism and negative regulation of ligand-induced signalling. The purpose of this review is to supply a detailed description of the TGF-β ligand-receptor network and oligomerisation patterns induced thereby, with special emphasis on the emerging and non-redundant roles of the accessory receptors of the TGF-β ligands in modulating receptor assembly and biological effects.
机译：TGF-β超家族成员通过结合I型，II型和III型细胞表面受体发挥其生物学作用。虽然I型和II型受体需要丝氨酸/苏氨酸激酶域并在配体结合后形成信号传导实体，但III型受体代表辅助受体，迄今尚未发现可识别的激酶功能。在TGF-β信号传导中，I和II型受体的异四聚体复合物在配体结合后被诱导，从而促进通过细胞内Smad蛋白的信号转导。最近的研究表明，I型和II型低聚动力学主要用于促进TGF-β配体的信号转导作用，也可以发挥功能拮抗作用和对配体诱导的信号转导的负调节作用。这篇综述的目的是提供TGF-β配体-受体网络和由此诱导的寡聚模式的详细描述，特别着重于TGF-β配体的辅助受体在调节受体中的新兴和非冗余作用组装和生物效应。

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