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首页> 外文期刊>ORL: Journal for oto-rhino-laryngology and its borderlands >CD24: A novel cancer biomarker in laryngeal squamous cell carcinoma
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CD24: A novel cancer biomarker in laryngeal squamous cell carcinoma

机译：CD24：喉鳞状细胞癌的新型癌症生物标志物

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Purpose: To investigate the role of CD24 in tumor invasion and the clinical significance of its expression in laryngeal squamous cell carcinoma (LSCC). Procedures: CD24 expression was measured in Hep-2 cell lines and tumor and peritumoral tissues by quantitative real-time PCR and Western blot analysis. The role of CD24 in LSCC was investigated by CD24 depletion using small interfering RNA. Tumor tissue microarrays with samples from 102 LSCC patients were used to detect expression of CD24 and proliferating cell nuclear antigen (PCNA). Prognostic significance was assessed using Kaplan-Meier survival estimates and log-rank tests. Results: CD24 was overexpressed in the LSCC cell line and in tumor tissues. Depletion of CD24 caused a notable decrease in cell proliferation, migration and invasiveness in vitro. High CD24 expression was significantly associated with T clinic stage, lymph node metastasis and tumor size (p < 0.05). Patients suffering from LSCC recurrence had higher levels of CD24 protein than those without recurrence (p < 0.0001). The proportion of patients with high PCNA expression was significantly greater among patients with CD24+ LSCC than those with CD24-LSCC (p = 0.000). Univariate and multivariate analyses revealed that CD24 was a significant predictor for overall survival. Conclusions: Overexpression of CD24 in LSCC is associated with invasiveness, metastatic potential and high tumor proliferation status. CD24 may be a promising strategy for the future treatment of LSCC metastasis and recurrence.
机译：目的：探讨CD24在喉癌中的作用及其在喉鳞状细胞癌中的表达及其临床意义。程序：通过实时定量PCR和Western印迹分析检测Hep-2细胞系以及肿瘤和肿瘤周围组织中CD24的表达。 CD24在LSCC中的作用通过使用小干扰RNA的CD24耗竭进行了研究。肿瘤组织微阵列与来自102名LSCC患者的样品一起用于检测CD24和增殖细胞核抗原（PCNA）的表达。使用Kaplan-Meier生存评估和对数秩检验评估预后的意义。结果：CD24在LSCC细胞系和肿瘤组织中过表达。 CD24的消耗导致体外细胞增殖，迁移和侵袭性显着降低。高CD24表达与T临床分期，淋巴结转移和肿瘤大小显着相关（p <0.05）。 LSCC复发患者的CD24蛋白水平高于未复发的患者（p <0.0001）。 CD24 + LSCC患者中PCNA高表达的患者比例明显高于CD24-LSCC患者（p = 0.000）。单因素和多因素分析表明，CD24是整体生存的重要预测指标。结论：LSCC中CD24的过表达与侵袭性，转移潜力和高肿瘤增殖状态有关。 CD24可能是未来治疗LSCC转移和复发的有前途的策略。

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