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首页> 外文期刊>ORL: Journal for oto-rhino-laryngology and its borderlands >Effect of corticosteroids or diuretics in low-tone sensorineural hearing loss.
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Effect of corticosteroids or diuretics in low-tone sensorineural hearing loss.

机译：皮质类固醇或利尿剂对低音感音神经性听力损失的作用。

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OBJECTIVES: We retrospectively analyzed 225 patients with acute low-tone sensorineural hearing loss (ALSHL), comparing the effectiveness of corticosteroid and diuretic therapy, and also determining the factors affecting hearing recovery. DESIGN: Retrospective clinical record review. METHODS: Multivariate logistic regression analysis. RESULTS: Analyses identified unfavorable factors such as aging, late initiation of treatment, and pretreatment pure-tone hearing thresholds at three lower frequencies adding up to 95 dB and more. Multivariate logistic regression analysis indicated a significantly greater improvement in hearing in patients treated with corticosteroids at high initial and total doses than in those treated with vitamin B12 and ATP without adding corticosteroids. In 145 patients treated with corticosteroids, multivariate logistic regression analysis showed a trend toward greater improvement with high initial and total doses than with low doses. CONCLUSION: Corticosteroids should be changed from low to high doses within 7 days after onset of ALSHL, if low doses are failing.
机译：目的：我们回顾性分析了225例急性低音感音神经性听力损失（ALSHL）患者，比较了皮质类固醇和利尿剂治疗的有效性，并确定了影响听力恢复的因素。设计：回顾性临床记录审查。方法：多元逻辑回归分析。结果：分析确定了不利因素，例如衰老，治疗起步较晚以及在三个较低的频率（合计95 dB以上）上的治疗前纯音听力阈值。多元逻辑回归分析表明，与不添加皮质类固醇的维生素B12和ATP相比，接受高剂量初始和总剂量皮质类固醇治疗的患者的听力改善显着。在145名接受皮质类固醇治疗的患者中，多因素logistic回归分析显示，高剂量的初始剂量和总剂量比低剂量的治疗有更大的改善趋势。结论：如果小剂量失败，应在ALSHL发作后7天内将皮质类固醇从低剂量改为高剂量。

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